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Background
‘Skin Shop’ is a model of care at a high‐volume tertiary centre that describes a registrar‐lead skin cancer service under consultant supervision. Ninety‐two percent of lesions are completely excised, 4.2% are narrowly excised and 3.2% are incompletely excised. Current international guidelines suggest re‐excision of incompletely excised non‐melanomatous skin cancer (NMSC); however, there...
Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyrosine phosphatase sigma (PTPRS) is expressed specifically on pDCs. Surface PTPRS was...
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