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Cationic polymer‐based biodelivery has attracted more and more attention in recent years because of their advantages including facilitated cellular internalization, efficient endo/lysosomal escape, and nuclear targeting. However, direct applications of cationic polymers encounter numerous problems such as cell damage, nonspecific interactions with blood components, and rapid clearance from the bloodstream...
A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like “bomblets”, enabling tumor penetration, cell internalization,...
Poly(β‐aminoester) dendrimers have been prepared. These systems represent the first degradable dual pH‐ and temperature‐responsive dendrimers displaying photoluminescence. The pH/temperature sensitivities are interrelated; the lower critical solution temperature of the dendrimer decreases as the pH of the solution is increased. The sensitivities are mainly due to phase changes of the surface groups...
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