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Aims/Purpose: Neurovascular dysfunction in glaucoma is exacerbated by aging. We recently deciphered the crucial role of the cytochrome P450 (CYP) metabolic pathway in the retina (R) and ophthalmic artery (OA). Vasoactive CYP metabolites are hydrolysed by soluble epoxide hydrolase (sEH), thereby diminishing their protective effects. Hence, sEH has emerged as a novel inhibitory target. This study defined...
Background
Although male factor accounts for 40%–50% of unintended childlessness, we are far from fully understanding the detailed causes. Usually, affected men cannot even be provided with a molecular diagnosis.
Objectives
We aimed at a higher resolution of the human sperm proteome for better understanding of the molecular causes of male infertility. We were particularly interested in why reduced...
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