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Memory T cells (Tm) represent a major barrier for immunosuppression and tolerance induction after solid organ transplantation. Taking into consideration the critical role of the intrinsic apoptosis pathway in the generation and maintenance of Tm, we developed a new concept to deplete alloreactive Tm by targeting Bcl‐2 proteins. The small‐molecule Bcl‐2/Bcl‐XL inhibitor ABT‐737 efficiently induced...