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We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies – mixed with 251 other MPN...
We examined inter‐ and intraobserver reproducibility and concordance between histological diagnosis and independently collected clinical findings in a large series of patients with the major subtypes of myeloproliferative neoplasms (MPNs) and controls. Seven hematopathologists reviewed 272 bone marrow biopsies including 43 controls. Diagnoses were determined according to the 2008 criteria of the World...
Madelung A, Bzorek M, Bondo H, Zetterberg E, Bjerrum O W, Hasselbalch H C, Scheding S & Ralfkiaer E (2012) Histopathology60, 554–560 A novel immunohistochemical sequential multi‐labelling and erasing technique enables epitope characterization of bone marrow pericytes in primary myelofibrosisAim: In Philadelphia (Ph)‐negative chronic myeloproliferative neoplasms, increased microvascular density,...
Risum M, Madelung A, Bondo H, Bzorek M, Kristensen MH, Stamp IM, Hasselbalch HC. The JAK2V617F allele burden and STAT3‐ and STAT5 phosphorylation in myeloproliferative neoplasms: early prefibrotic myelofibrosis compared with essential thrombocythemia, polycythemia vera and myelofibrosis. APMIS 2011; 119: 498–504.
Early prefibrotic myelofibrosis (early PMF) is a diagnosis that clinically and histologically...
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