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Objective
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic predisposition. Genome‐wide association studies (GWAS) of SLE have identified more than 50 robust susceptibility loci. However, traditional individual SNP‐based GWAS have made it difficult to identify variants with small effects. Moreover, variants revealed by GWAS only explain a limited disease heritability,...
Single‐nucleotide polymorphisms (SNPs) in the UHRF gene have been shown to be associated with systemic lupus erythematosus (SLE) in European and Hong Kong Chinese, but statistically significant evidence for association has not been found in a mainland Han Chinese population. Therefore, we selected SNP rs13205210 located in UHRF1BP1 as a candidate association from our previously published genome‐wide...
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