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In article number 1905925, Hui‐Hua Li, Fu‐Jian Xu, Jie Du, and co‐workers use a crosslinked heparin polysaccharide nanoparticle to coordinate delivery of vascular endothelial growth factor A/C (VEGF‐A/C) isoforms to improve cardiac function via intravenous injection at a dose ratio of 3:1 (VEGF‐C vs VEGF‐A). Excellent recovery of cardiac function is successfully demonstrated through improving collateral...
Protein‐based therapies are potential treatments for cancer, immunological, and cardiovascular diseases. However, effective delivery systems are needed because of their instability, immunogenicity, and so on. Crosslinked negatively charged heparin polysaccharide nanoparticle (HepNP) is proposed for protein delivery. HepNP can efficiently condense vascular endothelial growth factor (VEGF) because of...
Nucleic acid (NA)‐based therapy is proposed to address serious diseases such as cardiovascular diseases (CVDs). Powerful NA delivery vehicles are essential for effective gene therapy. Herein, a novel type of delivery vehicle, an unlockable core–shell nanocomplex (Hep@PGEA) with self‐accelerating NA release, is structurally designed. Hep@PGEA is composed of disulfide‐bridged heparin nanoparticle (HepNP)...
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