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The current study presents an innovative magnetic bead-based 3-dimensional (3D) micro-incubator for rapid purification of tumor cells (TCs) by using micro-electro-mechanical-systems (MEMS) technologies. With the incorporation of magnetic beads, specific antibodies conjugated onto the surface of the magnetic beads can be used to specifically recognize the TCs in the clinical body fluids, followed by...
We demonstrate that the efficiency of DNA hybridization could be improved by introducing elevated temperature in the hot region and higher velocities in the cold region of a microfluidic chip. Compared with the conventional methods, this hybridization microchip was shown to increase the hybridization signal 4.6-fold within 30 minutes using a 1.4 kb target DNA as the test material. The increase in...
This main purpose of this research is to develop the polymer material for polymerase chain reaction biochip. The microchip composed of two parts. One is the heater and temperature sensor on a top cover, the other is the microchannel and reaction chamber on a bottom substrate. Two kinds of chip were designed: 1. a glass cover and a TPX substrate, 2. a TPX cover and a TPX substrate. We utilized Poly-4-methyl-pentene-1...
Optical detection technique is critical for biomedical applications. The technique for optical fiber coupling is crucial for many optical detection applications. This study reports a new active two-axis micro coupler for buried optical fibers, which are commonly used for on-chip optical detection in microfluidic systems. The active micro coupler comprising air chambers, optical fiber channels, and...
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