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Blunted cortisol responses to stress or trauma have been linked with genetic (familial) risk for both alcoholism and post‐traumatic stress disorder (PTSD). Mouse lines selectively bred for high (HAP) or low (LAP) alcohol preference may be a relevant model of genetic risk for co‐morbid alcoholism and PTSD in humans. HAP mice show greater fear‐potentiated startle (FPS), a model used to study PTSD, than...
An additional class of endogenous lipid amides, N-arachidonoyl amino acids (Ara-AAs), is growing in significance in the field of endocannabinoids. The development, validation, and application of a sensitive and selective method to simultaneously monitor and quantify the level of Ara-AAs along with anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) in mouse brain has been established. The linearity...
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