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The anterior insular cortex (AIC) and its interconnected brain regions have been associated with both addiction and decision‐making under uncertainty. However, the causal interactions in this uncertainty‐encoding neurocircuitry and how these neural dynamics impact relapse remain elusive. Here, we used model‐based fMRI to measure choice uncertainty in a motor decision task in 61 individuals with cocaine...
The orbitofrontal cortex (OFC) is crucial for the inhibition of extraneous stimuli, evaluation of aversive information and emotional regulation—all behaviors impaired in cocaine addiction. Previous studies suggest that cocaine‐addicted subjects have decreased basal activity in the OFC. In this study, we examined regional cerebral blood flow (rCBF) during a saline infusion in two independent populations...
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