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Asymmetric functional divergence of paralogues is a key aspect of the traditional model of evolution following duplication. If one gene continues to perform the ancestral function while the other copy evolves a new function then we might expect a period of accelerated sequence evolution following duplication in one of the copies. In keeping with this prediction, many individual examples of asymmetric...
The 454 sequencing platform enables new investigatory methods for characterizing the diversity of a population, but is prone to sequencing errors such as homopolymer length miscalls which can lead to frame shift errors in analyses of protein coding sequences. We present an analysis methodology intended to correct such frame shift errors, distinguish between the remaining sequencing errors and noise...
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