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Purpose. During long-term treatment of various malignant or viral diseases with IFN-α up to 20% of patients develop anti-IFN-α antibodies for as yet unknown reasons. Methods. To address this issue, a mouse model using Balb/C mice was established and the relevance of several potentially anti-IFN-α antibodies inducing factors was studied. Results. The model revealed that both a higher frequency...
A conditional null allele for VCAM-1 was generated in mice through a one step ES cell selection procedure by flanking the proximal promoter and exons 1 and 2 with loxP sites. The ES cells were used to create chimeric mice, which were then used to produce mice homozygous for the VCAM-1 conditional null, or floxed allele. Although the PGKneo cassette was retained in the promoter, the homozygous mice...
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