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Background Both differential expression (DE) and differential co-expression (DC) analyses are appreciated as useful tools in understanding gene regulation related to complex diseases. The performance of integrating DE and DC, however, remains unexplored. Results In this study, we proposed a novel analytical approach called DECODE (Differential Co-expression and Differential Expression) to integrate...
Previously, we showed that hypoxia-inducible factor (HIF)-1α, HIF-2α, carbonic anhydrase IX (CA IX), and vascular endothelial growth factor (VEGF) were frequently coexpressed in tumor biopsies from patients of nasopharyngeal carcinoma (NPC) and were associated with poor outcome after radiotherapy. Here, we further studied hypoxic induction of HIF-1α, HIF-2α, CA IX, and VEGF in NPC cell lines, investigated...
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