Search results for: Mariette Labots

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Characterization of discordance between mismatch repair deficiency and microsatellite instability testing may prevent inappropriate treatment with immunotherapy

Birgit S Geurts, Laurien J Zeverijn, Jade M Berge Henegouwen, Hanneke Wijngaart, more

The Journal of Pathology > 263 > 3 > 288 - 299

In the Drug Rediscovery Protocol (DRUP), patients with cancer are treated based on their tumor molecular profile with approved targeted and immunotherapies outside the labeled indication. Importantly, patients undergo a tumor biopsy for whole‐genome sequencing (WGS) which allows for a WGS‐based evaluation of routine diagnostics. Notably, we observed that not all biopsies of patients with dMMR/MSI‐positive...

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Evaluation of the Khorana, PROTECHT, and 5‐SNP scores for prediction of venous thromboembolism in patients with cancer

Noori A. M. Guman, Roos J. van Geffen, Frits I. Mulder, Thijs F. van Haaps, more

Journal of Thrombosis and Haemostasis > 19 > 12 > 2974 - 2983

Background The Khorana score is a validated tool to identify cancer patients at higher risk of venous thromboembolism (VTE). Objective We compared its predictive performance to that of the clinical PROTECHT and the polygenic 5‐SNP scores in patients who participated in the Dutch CPCT‐02 study. Patients/methods Data on VTE and its risk factors were retrospectively collected for 2729 patients with...

article

Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes

Jetty A. Overbeek, Josephina G. Kuiper, Amber A. W. A. Heijden, Mariette Labots, more

International Journal of Colorectal Disease > 2019 > 34 > 2 > 269-276

Purpose The prevalence of colorectal cancer is higher among patients with type 2 diabetes mellitus (T2D) than among patients without diabetes. Furthermore, men are at higher risk for developing colorectal cancer than women in the general population and also subsite-specific risks differ per sex. The aim was to evaluate the impact of T2D on these associations. Methods A population-based matched cohort...

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Phosphotyrosine-based-phosphoproteomics scaled-down to biopsy level for analysis of individual tumor biology and treatment selection

Mariette Labots, Johannes C. van der Mijn, Robin Beekhof, Sander R. Piersma, more

Journal of Proteomics > 2017 > 162 > C > 99-107

Mass spectrometry-based phosphoproteomics of cancer cell and tissue lysates provides insight in aberrantly activated signaling pathways and potential drug targets. For improved understanding of individual patient's tumor biology and to allow selection of tyrosine kinase inhibitors in individual patients, phosphoproteomics of small clinical samples should be feasible and reproducible. We aimed to scale...

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Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines

Sander R. Piersma, Jaco C. Knol, Inge de Reus, Mariette Labots, more

Journal of Proteomics > 2015 > 127 > Part B > 247-258

Robust phosphopeptide enrichment methods with minimal fractionation are required to profile signaling network analysis in cancer cell lines and tissues. We assessed performance of single-shot LC-MS/MS label-free phosphoproteomics using TiOx-based phosphopeptide enrichment and report phosphopeptide identification reproducibility (75.8%), depth of identification (6014–6150 phosphopeptides) and reproducibility...

article

Evaluation of different phospho-tyrosine antibodies for label-free phosphoproteomics

Johannes C. van der Mijn, Mariette Labots, Sander R. Piersma, Thang V. Pham, more

Journal of Proteomics > 2015 > 127 > Part B > 259-263

Mass spectrometry based phosphoproteomics emerged as advantageous approach for the analysis of tyrosine phosphorylation on proteins and tyrosine kinase signaling. Immunoaffinity purification is required for comprehensive analysis. Here we compared the performance of two antibodies for label-free phosphotyrosine-based phosphoproteomics.Phosphopeptide immunoprecipitation of six technical replicates...

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High-level copy number gains of established and potential drug target genes in gastric cancer as a lead for treatment development and selection

Mariette Labots, Tineke E. Buffart, Josien C. Haan, Nicole C. T. Grieken, more

Cellular Oncology > 2014 > 37 > 1 > 41-52

Purpose The overall survival rate of patients with advanced gastric cancer is poor. Therefore, there is an urgent need for new treatment options for these patients. The identification of drug target genes located on DNA regions exhibiting high-level copy number gains (CNG) may be an effective approach, as has e.g. previously been shown for HER2. The aim of the present study was to identify putative...

article

Strategies for kinome profiling in cancer and potential clinical applications: chemical proteomics and array-based methods

Sander R. Piersma, Mariette Labots, Henk M. W. Verheul, Connie R. Jiménez

Analytical and Bioanalytical Chemistry > 2010 > 397 > 8 > 3163-3171

Kinases are key enzymes involved in deregulated signal transduction associated with cancer development and progression. The advent of personalized medicine drives the development of new diagnostic tools for patient stratification and therapy selection Ginsburg and Willard (Transl Res 154:277-287, 2009). Since deregulation of kinase-mediated signal transduction is implied in tumorigenesis, the analysis...

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Search results for: Mariette Labots

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