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Background Acute respiratory distress syndrome (ARDS) is associated with high mortality rates. ARDS patients suffer from severe hypoxemia, and extracorporeal membrane oxygenation (ECMO) therapy may be necessary to ensure oxygenation. ARDS has various etiologies, including trauma, ischemia-reperfusion injury or infections of various origins, and the associated immunological responses may vary. To support...
ObjectiveTo investigate the capacity of ADAM15, a disintegrin metalloproteinase that is up‐regulated in osteoarthritic (OA) cartilage, to protect chondrocytes against apoptosis induced by growth factor deprivation and genotoxic stress.
MethodsCaspase 3/7 activity was determined in primary OA and ADAM15‐transfected T/C28a4 chondrocytes upon exposure to the DNA‐damaging agent camptothecin or serum...
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