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Evolocumab has been shown to consistently reduce low-density lipoprotein cholesterol (LDL-C) across populations. The phase 3 studies included administration in the home-use and in-clinic settings but did not specifically evaluate the feasibility of home-use administration. Two clinical studies enrolled patients with hypercholesterolemia or mixed dyslipidemia on statin therapy and with/without ezetimibe...
The next generation UltraSPARC-I CPU represents a significant step forward in processor performance at the cost of increased design complexity. Added complexity increases the risks in achieving functionally correct first silicon. Existing design verification techniques were supplemented by applying emulation to obtain an early look at functionality. Discussed are the goals, methods and results of...
Increasing complexity of microprocessor-based systems puts pressure on a product's time-to-market. We describe a methodology used in designing the system interface of UltraSPARC-I. This methodology allowed us to define the system interface architecture, verify the functionality, perform timing and noise analysis and do the physical board design in parallel. This concurrency permitted rapid implementation...
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