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Insulin‐like growth factor (IGF)‐1 is essential for the development of the nervous system, and is present in many cell types. Relatively little is known about IGF‐1 expression in brain microvascular endothelial cells (BMECs). For in vivo studies, we examined the expression of IGF‐1 and insulin‐like growth factor‐binding protein (IGFBP)‐2 after focal cerebral ischemia for 12 h, 24 h, 3 days and 7 days,...
The permeability of the blood–brain barrier (BBB) is a bottleneck for the development of new cerebropathy medications because the medication must be transmitted across the BBB to achieve its curative function. To explore a new approach to the treatment of brain disease, this study investigated the mediating effects of brain microvascular endothelial cells (MVECs) on injured neurons.MVECs and cortical...
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