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The current study presents an innovative magnetic bead-based 3-dimensional (3D) micro-incubator for rapid purification of tumor cells (TCs) by using micro-electro-mechanical-systems (MEMS) technologies. With the incorporation of magnetic beads, specific antibodies conjugated onto the surface of the magnetic beads can be used to specifically recognize the TCs in the clinical body fluids, followed by...
This paper reports the completion of fundamental fluidic operation considered essential to build digital microfluidics system, which can be used for micro total analysis system (mu-TAS) or lab-on-a-chip by the coplanar electrode type of EWOD device. Coplanar electrode type of EWOD chip could be designed as a novel tool to delivery many kinds of bio-samples, such as DNA, enzyme, and salt solution without...
This paper presents a new integrated microfluidic chip that automatically performs ribonucleic acid (RNA) extraction and reverse transcription (RT) processes. The microfluidic system consists of a microfluidic control module and a magnetic bio-separator. The microfluidic control module can perform pumping and mixing of small amount of fluids and subsequent purification and concentration of RNA samples...
This study presents a new magnetic bead-based microfluidic platform, which integrates three major modules for rapid leukocytes purification, genomic DNA (gDNA) extraction and fast analysis of genetic gene. By utilizing microfluidic technologies and magnetic beads conjugated with CD15/45 antibodies, leukocytes in a human whole blood sample can be first purified and concentrated, followed by extraction...
The current study presents a new magnetic-bead-based microfiuidic platform integrating several modules, including a human WBC (white blood cells) pretreatment module, a DNA extraction module and a nucleic acid amplification module for fast detection of genetic diseases by utilizing the MEMS (micro-electro-mechanical-systems) technologies. By using antibodies-coated magnetic beads, WBC can be purified...
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