Search results for: Barbara Tolusso

Items from 1 to 20 out of 29 results

article

COVID‐19 illness: Different comorbidities may require different immunological therapeutic targets

Elisa Gremese, Barbara Tolusso, Dario Bruno, Anna Maria Paglionico, more

European Journal of Clinical Investigation > 53 > 12 > n/a - n/a

Background The SARS‐CoV‐2 pandemic has led to more than 6,870.000 deaths worldwide. Despite recent therapeutic advances, deaths in Intensive Care Units still range between 34 and 72%, comprising substantial unmet need as we move to an endemic phase. The general agreement is that in the first few days of infection, antiviral drugs and neutralizing monoclonal antibodies should be adopted. When the...

article

Inclusion of Synovial Tissue–Derived Characteristics in a Nomogram for the Prediction of Treatment Response in Treatment‐Naive Rheumatoid Arthritis Patients

Stefano Alivernini, Barbara Tolusso, Marco Gessi, Maria Rita Gigante, more

Arthritis & Rheumatology > 73 > 9 > 1601 - 1613

Objective This study applied a synovitis score obtained during routine care from ultrasound (US)–guided biopsies of synovial tissue (ST) in patients with rheumatoid arthritis (RA) and patients with other inflammatory and noninflammatory joint diseases to identify pretreatment synovial biomarkers associated with disease characteristics, and to integrate the findings into a multiparameter nomogram...

article

Basophil activation and serum IL‐5 levels as possible monitor biomarkers in severe eosinophilic asthma patients treated with anti‐IL‐5 drugs

Cristiano Caruso, Stefania Colantuono, Barbara Tolusso, Clara Di Mario, more

Allergy > 76 > 5 > 1569 - 1571

article

Basic immunology may lead to translational therapeutic rationale: SARS‐CoV‐2 and rheumatic diseases

Elisa Gremese, Edoardo Sean Ferraccioli, Stefano Alivernini, Barbara Tolusso, more

European Journal of Clinical Investigation > 50 > 9 > n/a - n/a

COVID‐19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an "immunological umbrella"...

article

Measuring the T‐cell down‐regulation of TCR‐zeta, ZAP‐70 and CD28 in arthritis patients: An old tool for new biomarkers

Gaetano Zizzo, Maria De Santis, Silvia Bosello, Barbara Tolusso, more

European Journal of Immunology > 49 > 12 > 2195 - 2203

Low T‐cell receptor (TCR)/CD28 signaling lymphocytes are expanded in arthritis. We asked whether the down‐expression of TCR‐related molecules correlates with specific arthritis characteristics and if it has clinical implications. TCR‐ZETA, ZAP‐70 and CD28 expression was measured by flow cytometry in synovial fluid (SF) and peripheral blood (PB)‐derived T cells. In PB, ZETA‐downregulation in CD4⁺CD28...

article

Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor/anti-citrulline antibody-negative rheumatoid arthritis

Stefano Alivernini, Dario Bruno, Barbara Tolusso, Laura Bui, more

Arthritis Research & Therapy > 2019 > 21 > 1 > 1-11

Background Differential diagnosis among psoriatic arthritis (PsA) and seronegative rheumatoid arthritis (Ab^neg RA) can be challenging particularly in the clinical setting of peripheral phenotype and autoantibodies seronegativity. The aim of the study was to identify synovial tissue (ST) biomarkers differentially expressed in PsA and Ab^neg RA and test their predictive value of therapeutic response...

article

Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve

Clara Di Mario, Luca Petricca, Maria Rita Gigante, Angelina Barini, more

Endocrine > 2019 > 63 > 2 > 405-405

The original version of this article unfortunately contained a mistake in given and family names of all the authors.

article

Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: Influence of the disease severity and therapy on the ovarian reserve

Clara Di Mario, Luca Petricca, Maria Rita Gigante, Angelina Barini, more

Endocrine > 2019 > 63 > 2 > 369-375

Purpose Systemic lupus erythematosus (SLE) mainly affects childbearing age women and pharmacological treatments may negatively influence the ovarian reserve. Anti-Müllerian hormone (AMH) could be a good biomarker for ovarian reserve. Methods AMH serum levels were assessed in 86 consecutive SLE female patients with regular menstrual cycle compared with 44 aged matched healthy controls. Clinical and...

article

Characterization of inflammatory cell infiltrate of scleroderma skin: B cells and skin score progression

Silvia Bosello, Cristiana Angelucci, Gina Lama, Stefano Alivernini, more

Arthritis Research & Therapy > 2018 > 20 > 1 > 1-11

Background The purpose of this study was to investigate the frequency and the distribution of inflammatory cell infiltrate in two sets of cutaneous biopsies derived from clinically affected and unaffected skin in patients with systemic sclerosis (SSc) and to test correlation between the cell infiltrate and the progression of skin involvement. Methods Skin was immunohistochemically assessed to identify...

article

Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons

Stefano Alivernini, Mauro Galeazzi, Hagit Peleg, Barbara Tolusso, more

Autoimmunity Reviews > 2017 > 16 > 11 > 1096-1102

Rheumatoid Arthritis (RA) is an autoimmune chronic disease that is characterized by the positivity of various antibodies, the most specific being autoantibodies against citrullinated antigens (ACPA). Despite ACPA are not arthritogenic by themselves, ACPA positive individuals have high risk of RA development and ACPA positivity is associated with severe erosive phenotype and higher mortality rate compared...

article

Erratum to: Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, more

Arthritis Research & Therapy > 2017 > 19 > 1 > 1-1

The online version of the original article can be found under doi: 10.1186/s13075-016-1190-z .

article

Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, more

Arthritis Research & Therapy > 2016 > 18 > 1 > 1-8

Background Recent works have suggested a possible link between interleukin (IL)-33 and B-cell biology. We aimed to study the possible association between serum IL-33 detection and response to rituximab (RTX) in rheumatoid arthritis (RA) patients in different cohorts with an accurate enzyme-linked immunosorbent assay (ELISA). Methods Serum IL-33, rheumatoid factor (RF), anti-cyclic citrullinated...

article

Thymosin β₄ and β₁₀ in Sjögren’s syndrome: saliva proteomics and minor salivary glands expression

Silvia Bosello, Giusy Peluso, Federica Iavarone, Barbara Tolusso, more

Arthritis Research & Therapy > 2016 > 18 > 1 > 1-8

Background In the present study, we investigated whether thymosin β (Tβ) in saliva and in minor salivary glands is differentially expressed in patients with primary Sjögren’s syndrome (pSS) and patients with autoimmune diseases (systemic sclerosis [SSc], systemic lupus erythematosus [SLE], and rheumatoid arthritis [RA], with and without sicca syndrome [ss]). Methods Saliva specimens of nine patients...

article

Tu1910 Ultrasound and Histologically Proven Paradoxical Arthritis in IBD Patients Treated With Anti-TNFα

Daniela Pugliese, Stefano Alivernini, Luisa Guidi, Luca Petricca, more

Gastroenterology > 2016 > 150 > 4(S1) > S975

article

Sa1978 Infliximab Trough Levels After Dose Optimization for Loss of Response Predict Outcome at One Year

Luisa Guidi, Daniela Pugliese, Manuela Marzo, Barbara Tolusso, more

Gastroenterology > 2016 > 150 > 4(S1) > S422

article

Weight Loss, The Obesity Paradox in Rheumatoid Arthritis: Is It a Paradox? Comment on the Article by Baker et al

Elisa Gremese, Barbara Tolusso, Gianfranco Ferraccioli

Arthritis & Rheumatology > 68 > 2 > 553 - 553

article

Could we use a lower dose of rituximab to treat rheumatoid arthritis in clinical practice: pros and cons?

Gianfranco Ferraccioli, Barbara Tolusso, Elisa Gremese

Arthritis Research & Therapy > 2016 > 18 > 1 > 1-3

The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has been shown that rituximab 500 mg twice, performs as well as 1 g twice, 2 weeks apart, in terms of the American College of Rheumatology (ACR)20 and ACR50, but not the ACR70. The choice should always...

article

Tapering and discontinuation of TNF-α blockers without disease relapse using ultrasonography as a tool to identify patients with rheumatoid arthritis in clinical and histological remission

Stefano Alivernini, Giusy Peluso, Anna Laura Fedele, Barbara Tolusso, more

Arthritis Research & Therapy > 2016 > 18 > 1 > 1-7

Background In this study, we assessed whether clinical and ultrasonography (US)-based remission could be used to select patients with rheumatoid arthritis (RA) eligible to taper and discontinue anti-TNF-α therapy after achievement of remission, looking at disease relapse. Methods Forty-two patients with RA in sustained remission who were receiving anti-TNF-α treatment (Disease Activity Score <1...

article

Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis

Gabriele Di Sante, Barbara Tolusso, Anna Laura Fedele, Elisa Gremese, more

EBioMedicine > 2015 > 2 > 12 > 2037-2045

Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and associates with HLA-DRB1*04. The Collagen IIp_261-273-specific T cell repertoire in the peripheral blood of DR4+ patients at the onset of the disease shows a restricted TCR-beta chain usage among which the most frequent is TRBV25.To define whether this group of DR4-restricted collagen-specific shared T cell could represent...

article

The pathway toll like receptor 2 — CD44: A pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease

Gabriele Di Sante, Mariagrazia Valentini, Alessia Piermattei, Giuseppe Migliara, more

Journal of Neuroimmunology > 2014 > 275 > 1-2 > 58

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INFONA - science communication portal

Search results for: Barbara Tolusso

COVID‐19 illness: Different comorbidities may require different immunological therapeutic targets

Inclusion of Synovial Tissue–Derived Characteristics in a Nomogram for the Prediction of Treatment Response in Treatment‐Naive Rheumatoid Arthritis Patients

Basophil activation and serum IL‐5 levels as possible monitor biomarkers in severe eosinophilic asthma patients treated with anti‐IL‐5 drugs

Basic immunology may lead to translational therapeutic rationale: SARS‐CoV‐2 and rheumatic diseases

Measuring the T‐cell down‐regulation of TCR‐zeta, ZAP‐70 and CD28 in arthritis patients: An old tool for new biomarkers

Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor/anti-citrulline antibody-negative rheumatoid arthritis

Correction to: Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve

Anti-Müllerian hormone serum levels in systemic lupus erythematosus patients: Influence of the disease severity and therapy on the ovarian reserve

Characterization of inflammatory cell infiltrate of scleroderma skin: B cells and skin score progression

Is ACPA positivity the main driver for rheumatoid arthritis treatment? Pros and cons

Erratum to: Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

Thymosin β₄ and β₁₀ in Sjögren’s syndrome: saliva proteomics and minor salivary glands expression

Tu1910 Ultrasound and Histologically Proven Paradoxical Arthritis in IBD Patients Treated With Anti-TNFα

Sa1978 Infliximab Trough Levels After Dose Optimization for Loss of Response Predict Outcome at One Year

Weight Loss, The Obesity Paradox in Rheumatoid Arthritis: Is It a Paradox? Comment on the Article by Baker et al

Could we use a lower dose of rituximab to treat rheumatoid arthritis in clinical practice: pros and cons?

Tapering and discontinuation of TNF-α blockers without disease relapse using ultrasonography as a tool to identify patients with rheumatoid arthritis in clinical and histological remission

Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis

The pathway toll like receptor 2 — CD44: A pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease

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