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Lung adenocarcinoma is the leading cause of cancer deaths in the United States. This subtype of lung cancer shows an average five-year survival rate of 15–17%, which is mainly due to late diagnosis and specific prognostic evaluation for therapy recommendation. There is an urgent need for developing reliable prognostic biomarkers to predict the success of the therapy and devise effective treatment...
Background Fragment-based approaches have now become an important component of the drug discovery process. At the same time, pharmaceutical chemists are more often turning to the natural world and its extremely large and diverse collection of natural compounds to discover new leads that can potentially be turned into drugs. In this study we introduce and discuss a computational pipeline to automatically...
Alternative translation initiation sites (aTIS) and the factors that determine an ideal mode of translation of mRNA in the eukaryotic system has been widely studied over the past several decades. Such studies demonstrate that single mRNA can yield multiple protein isoforms using the AUG and non-AUG start codons. While the conspicuous scanning model explains how the process of translation initiation...
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