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Background The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity. Methods A cross-sectional prospective study was conducted to identify the frequency distribution of GSTM1 and GSTT1 alleles in 129 Tunisian epileptic patients treated with carbamazepine. Null alleles were determined...
Glutathione-S-transferases enzymes are involved in the detoxification of several endogenous and exogenous substances. These genetic pathways could be involved in the therapeutic efficacy and toxic effects of carbamazepine by modulating metabolic profiles. In this present study, we evaluated the effects of two glutathione-S-transferase polymorphisms, GSTM1 and GSTT1, on metabolic phenotype of carbamazepine...
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