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Background Detecting homologous protein sequences and computing multiple sequence alignments (MSA) are fundamental tasks in molecular bioinformatics. These tasks usually require a substitution matrix for modeling evolutionary substitution events derived from a set of aligned sequences. Over the last years, the known sequence space increased drastically and several publications demonstrated that this...
Background BLOSUM matrices belong to the most commonly used substitution matrix series for protein homology search and sequence alignments since their publication in 1992. In 2008, Styczynski et al. discovered miscalculations in the clustering step of the matrix computation. Still, the RBLOSUM64 matrix based on the corrected BLOSUM code was reported to perform worse at a statistically significant...
Proteins are essential parts in all living organisms. They consist of sequences of amino acids. An interaction with reactive agent can stimulate a mutation at a specific position in the sequence. This mutation may set off a chain reaction, which effects other amino acids in the protein. Chain reactions need to be analyzed, as they may invoke unwanted side effects in drug treatment. A mutation chain...
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