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We present a biosensor system comprising a chip with an array of silicon nanowire ISFETs and a CMOS chip with the signal-conditioning circuitry. An array of 48 silicon nanowires has been patterned via e-beam lithography. The on-chip circuitry is used to monitor the resistance of the nanowires by applying a constant voltage and measuring the respective current. The analog signal is then digitized on...
Biosensor microprobe arrays for the simultaneous in vivo detection of the neurotransmitters choline and L-glutamate are presented. Combined with a custom-developed CMOS chip, comprising 24 potentiostatic circuits, recordings can be performed at high signal-to-noise ratio in multiple areas of a rat's brain in parallel. The functionalization to create selective enzyme electrodes is based on electrochemical...
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