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The buccal epithelium of male patients with paranoid schizophrenia at different stages of treatment was characterized by a reduced fraction of cells with micronuclei, central circular notches, “broken egg” protrusions, and an increased frequency of cells with karyorrhexis. A modified nonlinear frequency of binuclear cells, cells with karyolysis, “tongue” protrusions and perinuclear vacuoles, was observed...