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Background and Objectives A clinical trial was conducted to measure and analyse the pharmacokinetic parameters of a lipid formulation of risperidone, VAL401. The VAL401 formulation is designed to repurpose risperidone from an antipsychotic to an adenocarcinoma treatment, with the lipid formulation altering the cellular uptake of risperidone, thus enabling anticancer biology to be exhibited in preclinical...
Disruptions in cognitive function have been described in the constellation of symptoms associated with “asymptomatic” primary hyperparathyroidism (PHPT). The aim of this study was to determine the impact of parathyroidectomy (PTX) on brain function and sleep in “asymptomatic” PHPT patients.We conducted a prospective, randomized trial comparing immediate PTX with observation in patients with asymptomatic...
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