Search results for: Felix Nguyen

Items from 1 to 20 out of 34 results

article

Risk stratification after recurrence of human papillomavirus (HPV)‐related and non‐HPV‐related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522

Elaine O. Bigelow, Jonathan Harris, Carole Fakhry, Maura L. Gillison, more

Background No risk‐stratification strategies exist for patients with recurrent oropharyngeal cancer (OPC). Methods Retrospective analysis using data from prospective NRG Oncology clinical trials RTOG 0129 and 0522. Eligibility criteria included known p16 status and smoking history, and locoregional/distant recurrence. Overall survival (OS) was measured from date of recurrence. Recursive partitioning...

article

Phase II study of de‐intensified intensity‐modulated radiotherapy and concurrent carboplatin/5‐fluorouracil in lateralized p16‐associated oropharyngeal carcinoma

Houda Bahig, Louise Lambert, Edith Filion, Denis Soulières, more

Head & Neck > 42 > 12 > 3479 - 3489

Purpose To assess cancer control and patient‐reported outcomes (PROs) after de‐intensified intensity‐modulated radiotherapy (IMRT) in lateralized p16‐associated oropharyngeal cancer (p16‐OPC). Methods Lateralized p16‐OPC treated with radiotherapy and concurrent Carboplatin/5‐fluorouracil between 2011 and 2014 were enrolled. De‐intensified IMRT consisted in elective neck dose of 43.2 Gy/24 fractions...

article

Cystic masses of the lateral neck: Diagnostic value comparison between fine‐needle aspiration, core‐needle biopsy, and frozen section

Paul Tabet, Nadim Saydy, Laurent Letourneau‐Guillon, Olga Gologan, more

Head & Neck > 41 > 8 > 2696 - 2703

Background The usefulness of fine‐needle aspiration (FNA), core‐needle biopsy (CNB), and frozen section (FS) for assessing lateral cystic neck masses (LCNM) remains unclear. Methods A retrospective review of patients presenting with a LCNM was undertaken. Results In total, 135 patients were included. FNA had a lower sensitivity then CNB (59% vs 83%; P = .036) and FS (59% vs 93%; P = .01). FS...

article

Validation of NRG oncology/RTOG‐0129 risk groups for HPV‐positive and HPV‐negative oropharyngeal squamous cell cancer: Implications for risk‐based therapeutic intensity trials

Carole Fakhry, Qiang Zhang, Maura L. Gillison, Phuc Felix Nguyen‐Tân, more

Cancer > 125 > 12 > 2027 - 2038

Background Radiation Therapy Oncology Group (RTOG)‐0129 recursive partitioning analysis was the basis for risk‐based therapeutic intensification trials for oropharyngeal cancer (OPC). To the authors’ knowledge, the question of whether RTOG‐0129 overall survival (OS) estimates for low‐risk, intermediate‐risk, and high‐risk groups are similar in other data sets or applicable to progression‐free survival...

article

Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study

Claudie Laprise, Sreenath Arekunnath Madathil, Nicolas F. Schlecht, Geneviève Castonguay, more

Head & Neck > 41 > 3 > 678 - 685

Background This study aimed to estimate the extent to which oral sex behavior is associated with an increased risk of oropharyngeal cancers (OPCs), and how much of the association is mediated by oral human papillomavirus (HPV) infection. Methods We used data from a hospital‐based case‐control study conducted in Montreal, Canada. Information on oral sex behaviors was collected. Oral rinse and oral...

article

A New Automatically Fixating Stone Basket (2.5 F) Prototype with a Nitinol Spring for Accurate Ureteroscopic Stone Size Measurement

Jens Cordes, Felix Nguyen, Wolfhard Pinkowski, Axel S. Merseburger, more

Advances in Therapy > 2018 > 35 > 9 > 1420-1425

Introduction Intraoperative assessment of stone size is crucial for the successful and safe extraction of stones. The first automatically fixating measuring stone basket prototype showed a mismatch between the steel spring and the nitinol basket; therefore, to improve this prototype, the steel spring was replaced with a nitinol spring and a modified scale was implemented on the basket handle for accurate...

article

Pre-irradiation dental care: Ready-to-use templates for oropharyngeal cancers

Raphaël Jumeau, Phuc Félix Nguyen-Tan, Houda Bahig, Xavier Liem, more

Reports of Practical Oncology & Radiotherapy > 2018 > 23 > 4 > 270-275

To develop a tool in order to guide pre-irradiation dental care (PIDC) for patients with oropharyngeal cancers.Osteoradionecrosis of the jaws is a potential complication of radiotherapy (RT) for head and neck cancers. To prevent this complication, PIDC can involve multiple dental extractions as a preventative measure to avoid post-RT complications. However, there is no standardized tool to guide PIDC...

article

Larynx motion considerations in partial larynx volumetric modulated arc therapy for early glottic cancer

Houda Bahig, Phuc Félix Nguyen‐Tan, Édith Filion, David Roberge, more

Journal of Medical Imaging and Radiation Oncology > 61 > 5 > 666 - 673

Introduction To assess laryngeal motion in early glottic cancer in order to determine safe margins for partial larynx volumetric modulated arc therapy (PL‐VMAT), and to quantify dosimetric advantages of PL‐VMAT. Methods This prospective study included T1‐2N0 glottic cancers treated with whole larynx VMAT (WL‐VMAT). Pre‐ and mid‐treatment 4D‐computed tomography (4D‐CT) and dynamic magnetic resonance...

article

Four PTEN‐targeting co‐expressed miRNAs and ACTN4‐ targeting miR‐548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue

Ilyes Berania, Guillaume B. Cardin, Isabelle Clément, Louis Guertin, more

International Journal of Cancer > 141 > 11 > 2318 - 2328

The purpose of this study was to determine the prognostic value and oncogenic pathways associated to miRNA expression in squamous cell carcinoma of the oral tongue and to link these miRNA candidates with potential gene targets. We performed a miRNA screening within our institutional cohort (n = 58 patients) and reported five prognostic targets including a cluster of four co‐expressed miRNAs (miR‐18a,...

article

Human papillomavirus genotypes and risk of head and neck cancers: Results from the HeNCe Life case-control study

Claudie Laprise, Sreenath Arekunnath Madathil, Nicolas F. Schlecht, Geneviève Castonguay, more

Oral Oncology > 2017 > 69 > C > 56-61

Human papillomaviruses (HPV) are changing dramatically the epidemiologic landscape of head and neck cancers (HNCs). Their role in the aetiology of these cancers varies widely among HNCs subsites, sex and geographical regions worldwide. We describe HPV prevalence and its association with HNCs risk overall and by anatomical subsite in a sample of Canadians.The HeNCe Life study recruited 460 incident...

article

Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Locally Advanced Head and Neck Carcinoma: NRG Oncology Radiation Therapy Oncology Group 0522

Minh Tam Truong, Qiang Zhang, David I. Rosenthal, Marcie List, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 97 > 4 > 687-699

To analyze the quality of life (QOL) and performance status (PS) (secondary outcome) in patients with stage III to IV head and neck cancer (HNC) enrolled on a prospective randomized phase 3 trial comparing radiation-cisplatin without cetuximab (CIS) or with cetuximab (CET/CIS). The QOL hypothesis proposed a between-arm difference in Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN) total...

article

Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Standard Radiation Versus Accelerated Radiation Plus Cisplatin for Locally Advanced Head and Neck Carcinoma: NRG Oncology RTOG 0129

Canhua Xiao, Qiang Zhang, Phuc Felix Nguyen-Tân, Marcie List, more

International Journal of Radiation Oncology*Biology*Physics > 2017 > 97 > 4 > 667-677

To analyze quality of life (QOL) and performance status (PS) for head and neck cancer (HNC) patients treated on NRG Oncology RTOG 0129 by treatment (secondary outcome) and p16 status, and to examine the association between QOL/PS and survival.Eligible patients were randomized into either an accelerated-fractionation arm or a standard-fractionation arm, and completed the Performance Status Scale for...

article

Exploratory Factor Analysis of NRG Oncology's University of Washington Quality of Life Questionnaire—RTOG Modification

Stephanie L. Pugh, Gwen Wyatt, Raimond K.W. Wong, Stephen M. Sagar, more

Journal of Pain and Symptom Management > 2017 > 53 > 1 > 139-145.e2

The 15-item University of Washington Quality of Life questionnaire–Radiation Therapy Oncology Group (RTOG) modification (UW-QOL–RTOG modification) has been used in several trials of head and neck cancer conducted by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537.This study is an exploratory factor analysis (EFA) to establish validity and reliability of the instrument subscales...

article

Prognostic Value of p16 Status on the Development of a Complete Response in Involved Oropharynx Cancer Neck Nodes After Cisplatin-Based Chemoradiation: A Secondary Analysis of NRG Oncology RTOG 0129

Thomas J. Galloway, Qiang (Ed) Zhang, Phuc Felix Nguyen-Tan, David I. Rosenthal, more

International Journal of Radiation Oncology*Biology*Physics > 2016 > 96 > 2 > 362-371

To determine the relationship between p16 status and the regional response of patients with node-positive oropharynx cancer treated on NRG Oncology RTOG 0129.Patients with N1-N3 oropharynx cancer and known p16 status who underwent treatment on RTOG 0129 were analyzed. Pathologic complete response (pCR) rates in patients treated with a postchemoradiation neck dissection (with p16-positive or p16-negative...

article

Palliative Radiation Therapy for Advanced Head and Neck Carcinomas: A Phase 2 Study

Bernard Fortin, Nader Khaouam, Edith Filion, Phuc Felix Nguyen-Tan, more

International Journal of Radiation Oncology*Biology*Physics > 2016 > 95 > 2 > 647-653

Incurable head and neck cancer is hard to manage with usual palliative care. Radiation therapy (RT) in this setting is sometimes omitted because there is an apprehension that the side effects in the head and neck region might counterbalance the benefits. The objective of this phase 2 study was to evaluate whether highly conformal RT could improve the therapeutic ratio with this comprehensive Quality...

article

A comparison between an in vitro ureteroscopic stone size estimation and the stone size measurement with the help of a scale on stone baskets

Jens Cordes, Lisa Teske, Felix Nguyen, Wolfhard Pinkowski, more

World Journal of Urology > 2016 > 34 > 9 > 1303-1309

Introduction Endoscopic treatment of ureter stones and renal calculi relies on the surgeon’s estimation of the stone size for both lithotripsy and removal of stones or stone fragments. We therefore compared precision and reliability of the endoscopic estimation of stone size by the surgeon with measurements on a scale on a stone basket. Materials and methods Two surgeons (one high experienced...

article

Predictive factors of survival and treatment tolerance in older patients treated with chemotherapy and radiotherapy for locally advanced head and neck cancer

Houda Bahig, Bernard Fortin, Moein Alizadeh, Louise Lambert, more

Oral Oncology > 2015 > 51 > 5 > 521-528

To report outcomes and predictive factors of overall survival, hospitalization and treatment completion rates in elderly patients with locally advanced head and neck cancer treated with concurrent chemoradiotherapy (CRT).A retrospective analysis of patients aged 70years or older treated with concurrent CRT for locally advanced head and neck cancer was conducted. Univariate and multivariate analysis...

article

North-American survey on HPV-DNA and p16 testing for head and neck squamous cell carcinoma

Anastasios Maniakas, Sami P. Moubayed, Tareck Ayad, Louis Guertin, more

Oral Oncology > 2014 > 50 > 10 > 942-946

Human papillomavirus (HPV)-positive head and neck squamous cell carcinomas (HNSCC) have been shown to have a significantly better prognosis and response to current treatment modalities. Current guidelines recommend systematic HPV-DNA and/or p16 testing on HNSCCs, although treatment approach should not be directed by test results. The objectives of this study were to (1) assess whether HPV-DNA and/or...

article

Xerostomia in patients treated for oropharyngeal carcinoma: Comparing linear accelerator–based intensity‐modulated radiation therapy with helical tomotherapy

Israël Fortin, Bernard Fortin, Louise Lambert, Sébastien Clavel, more

Head & Neck > 36 > 9 > 1343 - 1348

BackgroundIn comparison to sliding‐window intensity‐modulated radiation therapy (sw‐IMRT), we hypothesized that helical tomotherapy (HT) would achieve similar locoregional control and, at the same time, decrease the parotid gland dose, thus leading to a xerostomia reduction. MethodsThe association between radiation techniques, mean parotid dose, and xerostomia incidence, was reviewed in 119 patients...

article

Risk factors for clinician‐reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129

Canhua Xiao, Alexandra Hanlon, Qiang Zhang, Benjamin Movsas, more

Cancer > 120 > 6 > 848 - 854

BACKGROUNDChemoradiotherapy has become the standard of care for head and neck squamous cell carcinoma; however, those patients often experience multiple treatment‐related symptoms or symptom clusters. Two symptom clusters have been identified for this population. Little is known about the risk factors of these symptom clusters. METHODSSubjects comprised 684 patients who were treated with concurrent...

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INFONA - science communication portal

Search results for: Felix Nguyen

Risk stratification after recurrence of human papillomavirus (HPV)‐related and non‐HPV‐related oropharyngeal cancer: Secondary analysis of NRG Oncology RTOG 0129 and 0522

Phase II study of de‐intensified intensity‐modulated radiotherapy and concurrent carboplatin/5‐fluorouracil in lateralized p16‐associated oropharyngeal carcinoma

Cystic masses of the lateral neck: Diagnostic value comparison between fine‐needle aspiration, core‐needle biopsy, and frozen section

Validation of NRG oncology/RTOG‐0129 risk groups for HPV‐positive and HPV‐negative oropharyngeal squamous cell cancer: Implications for risk‐based therapeutic intensity trials

Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study

A New Automatically Fixating Stone Basket (2.5 F) Prototype with a Nitinol Spring for Accurate Ureteroscopic Stone Size Measurement

Pre-irradiation dental care: Ready-to-use templates for oropharyngeal cancers

Larynx motion considerations in partial larynx volumetric modulated arc therapy for early glottic cancer

Four PTEN‐targeting co‐expressed miRNAs and ACTN4‐ targeting miR‐548b are independent prognostic biomarkers in human squamous cell carcinoma of the oral tongue

Human papillomavirus genotypes and risk of head and neck cancers: Results from the HeNCe Life case-control study

Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Locally Advanced Head and Neck Carcinoma: NRG Oncology Radiation Therapy Oncology Group 0522

Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Standard Radiation Versus Accelerated Radiation Plus Cisplatin for Locally Advanced Head and Neck Carcinoma: NRG Oncology RTOG 0129

Exploratory Factor Analysis of NRG Oncology's University of Washington Quality of Life Questionnaire—RTOG Modification

Prognostic Value of p16 Status on the Development of a Complete Response in Involved Oropharynx Cancer Neck Nodes After Cisplatin-Based Chemoradiation: A Secondary Analysis of NRG Oncology RTOG 0129

Palliative Radiation Therapy for Advanced Head and Neck Carcinomas: A Phase 2 Study

A comparison between an in vitro ureteroscopic stone size estimation and the stone size measurement with the help of a scale on stone baskets

Predictive factors of survival and treatment tolerance in older patients treated with chemotherapy and radiotherapy for locally advanced head and neck cancer

North-American survey on HPV-DNA and p16 testing for head and neck squamous cell carcinoma

Xerostomia in patients treated for oropharyngeal carcinoma: Comparing linear accelerator–based intensity‐modulated radiation therapy with helical tomotherapy

Risk factors for clinician‐reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129

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