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Recently, it has been demonstrated that Glucagon-like peptide-1 (GLP-1) has a protective effect on endothelial cells. Our hypothesis is that this GLP-1 protective effect is partly lost when the cells are exposed to sustained high glucose concentrations. Human umbilical vein endothelial cells (HUVECs) were cultured for 21 days in normal glucose (5 mmol/L, NG) or high glucose (25 mmol/L glucose, HG)...
Aim High glucose-induced oxidative stress has been suggested as one of the mediators of endothelial damage in diabetes. The major endothelial protein, endoglin, has been found overexpressed in the vessels during pathological situations, but little is known about its relation to diabetic vascular complications. To clarify the role of endoglin in endothelial injury, we sought to determine the effects...
Riassunto Dagli inizi del XX secolo lo studio dei processi legati all’invecchiamento rappresenta uno degli argomenti più affascinanti della biologia. Numerose teorie furono elaborate per riuscire a comprendere del tutto o parzialmente quale siano i fattori chiave dell’invecchiamento: dalla teoria dei radicali liberi a quella della regolazione genica, dalla teoria della senescenza cellulare all’inflammaging...
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