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A miniature CMOS optoelectronic biosensor is proposed for screening whitening agents. Based on the principle of absorption photometry, this biosensor is mainly composed of a green LED, a CMOS phototransistor, and a slide for performing the biochemical reactions. The requirement of the sample volume is only 10 mul, much less than those in commercial instruments. Melanin assay and MTT assay were performed...
A miniature optical biosensing system based on a PMOS phototransistor and absorption photometry is proposed. The phototransistor was manufactured in a standard 0.35-mum CMOS process, and it exhibited a responsivity higher than 1000 A/W for 650-nm light. For biochemical applications, the TMB/H2O2/HRP method was adopted as a useful basis in our system. A sample volume of only 10 mul was required to...
An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-mu m CMOS technology. The ABTS/H2O2/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can...
In this report, a CMOS-compatible colorimetric biosensor based on HRP/TMB/streptavidin system is proposed. HRP activity is used for labelled target quantification by photometric detector. The modulation of light intensity due to enzyme reaction can easily be detected in 96 - well microarray plate by providing 650 nm light source (LED). There is good correlation between absorbance in 650 nm and the...
This paper proposes a high-sensitivity biosensing system on the basis of absorption photometry and a phototransistor. Manufactured in a standard 0.35-mum CMOS technology, the phototransistor exhibits a responsivity higher than 1000 A/W for 650-nm light. The TMB/H2O2/HRP method is chosen as a useful platform to determine the amount of various interesting targets. For the biochemical detection, a sample...
Colorimetric, in situ, isothermal rolling circle amplification (RCA)-based biosensor was developed as a novel, versatile nucleic acid-based amplification machine for platelet-derived growth factor (PDGF) detection. This antibody-free biosensor utilized nucleic acids immobilized on the plate and DNA aptamers to capture the target protein. As compared to the conventional fluorescence measurement [1],...
A CMOS-compatible optical biosensing system based on visible absorption spectroscopy is proposed. Within the compact prototype, the CMOS sensor consisting a P+/Nwell finger photodiode and a transimpedance amplifier (TIA) is implemented in a standard 0.35-mum CMOS technology. The ABTS/H2O2/HRP method is adopted as the ground for medical diagnosis. Experimental results demonstrate that the minimum concentration...
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