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Purpose To investigate the protein–protein interactions of a highly concentrated antibody solution that could cause oligomerization or aggregation and to develop a better understanding of the optimization of drug formulations. Methods In this study, we used Raman spectroscopy to investigate the structure and interactions of a highly concentrated antibody solution over a wide range of concentrations...
We used Raman spectroscopy to investigate the structure and interactions of lysozyme molecules in solution over a wide range of concentrations (2.5–300 mg ml−1). No changes in the amide‐I band were observed as the concentration was increased, but the width of the Trp band at 1555 cm−1 and the ratios of the intensities of the Tyr bands at 856 and 837 cm−1, the Trp bands at 870 and 877 cm−1, and the...
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