Search results for: Jingjing Deng

Items from 1 to 20 out of 46 results

article

Macrocyclic Encapsulation in a Non‐fused Tetrathiophene Acceptor for Efficient Organic Solar Cells with High Short‐Circuit Current Density

Shuaishuai Shen, Yu Mi, Yanni Ouyang, Yi Lin, more

Angewandte Chemie International Edition > 62 > 52 > n/a - n/a

Non‐fullerene acceptors have shown great promise for organic solar cells (OSCs). However, challenges in achieving high efficiency molecular system with conformational unicity and effective molecular stacking remain. In this study, we present a new design of non‐fused tetrathiophene acceptor R4T‐1 via employing the encapsulation of tetrathiophene with macrocyclic ring. The single crystal structure...

article

Macrocyclic Encapsulation in a Non‐fused Tetrathiophene Acceptor for Efficient Organic Solar Cells with High Short‐Circuit Current Density

Shuaishuai Shen, Yu Mi, Yanni Ouyang, Yi Lin, more

Angewandte Chemie > 135 > 52 > n/a - n/a

article

Clinical application of metagenomic next‐generation sequencing technology in the diagnosis and treatment of pulmonary infection pathogens: A prospective single‐center study of 138 patients

Na Li, Xiaolong Ma, Jiaqi Zhou, Jingjing Deng, more

Journal of Clinical Laboratory Analysis > 36 > 7 > n/a - n/a

Introduction Rapid and accurate pathogen identification is essential for the treatment of pneumonia. Metagenomic next‐generation sequencing (mNGS) is a newly developed technology to obtain microbial nucleic acid sequence information quickly, efficiently, and without bias. Methods We performed shotgun metagenomic next‐generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) for pathogen...

article

Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats

Ming Chu, Guofeng Fu, Jingjing Deng, Ruoxi Wang, more

Journal of Applied Toxicology > 42 > 8 > 1396 - 1410

Arecoline is a pharmacologically active alkaloid isolated from Areca catechu. There are no published data available regarding the inhalation toxicity of arecoline in animals. This study aimed to evaluate the inhalation toxicity of arecoline in vitro and in vivo. For this purpose, arecoline benzoate (ABA) salt was prepared to stabilize arecoline in an aerosol. The MTT assay determined the half‐maximal...

article

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Yusai Zhou, Jingjing Deng, Yi Zhang, Cong Li, more

Advanced Materials > 34 > 27 > n/a - n/a

Programmable base pair interactions at the nanoscale make DNA an attractive scaffold for forming hydroxyapatite (HAP) nanostructures. However, engineering macroscale HAP mineralization guided by DNA molecules remains challenging. To overcome this issue, a facile strategy is developed for the fabrication of ultrastiff DNA–HAP bulk composites. The electrostatic complexation of DNA and a surfactant with...

article

Controlling Enamel Remineralization by Amyloid‐Like Amelogenin Mimics

Dong Wang, Jingjing Deng, Xuliang Deng, Changqing Fang, more

Advanced Materials > 32 > 31 > n/a - n/a

In situ regeneration of the enamel‐like structure of hydroxyapatite (HAp) crystals under oral conditions is significant for dental caries treatment. However, it is still a challenge for dentists to duplicate the elegant and well‐aligned apatite structure bonding to the surface of demineralized enamel. A biocompatible amelogenin‐inspired matrix, a phase‐transited lysozyme (PTL) film mimicking an N‐terminal...

article

Amyloid‐Like Rapid Surface Modification for Antifouling and In‐Depth Remineralization of Dentine Tubules to Treat Dental Hypersensitivity

Chen Li, Danyang Lu, Jingjing Deng, Xu Zhang, more

Advanced Materials > 31 > 46 > n/a - n/a

Exposure of dentinal tubules (DTs) leads to the transmission of external stimuli within the DTs, causing dental hypersensitivity (DH). To treat DH, various desensitizers have been developed for occluding DTs. However, most desensitizers commercially available or in development are only able to seal the orifices, rather than the deep regions of the DTs, thus lacking long‐term stability. Herein, it...

article

Real-time moving pedestrian detection using contour features

Kai Zhao, Jingjing Deng, Deqiang Cheng

Multimedia Tools and Applications > 2018 > 77 > 23 > 30891- 30910

Pedestrian detection is one of the most fundamental research in computer vision. However, many high performance detectors run slowly. In this paper, we propose a real-time moving pedestrian detector by using efficient contour features. Firstly, the moving targets are detected by background subtraction. By combining the elliptic Fourier descriptors and the normalized central moments, we propose the...

article

A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

Zheng Wang, Micah D. Gearhart, Yu-Wei Lee, Ishan Kumar, more

Cell Stem Cell > 2018 > 22 > 2 > 235-251.e9

Polycomb group proteins regulate self-renewal and differentiation in many stem cell systems. When assembled into two canonical complexes, PRC1 and PRC2, they sequentially deposit H3K27me3 and H2AK119ub histone marks and establish repressive chromatin, referred to as Polycomb domains. Non-canonical PRC1 complexes retain RING1/RNF2 E3-ubiquitin ligases but have unique sets of accessory subunits. How...

article

Estimating the accuracy of a reduced‐order model for the calculation of fractional flow reserve (FFR)

Etienne Boileau, Sanjay Pant, Carl Roobottom, Igor Sazonov, more

International Journal for Numerical Methods in Biomedical Engineering > 34 > 1 > n/a - n/a

Image‐based noninvasive fractional flow reserve (FFR) is an emergent approach to determine the functional relevance of coronary stenoses. The present work aimed to determine the feasibility of using a method based on coronary computed tomography angiography (CCTA) and reduced‐order models (0D‐1D) for the evaluation of coronary stenoses. The reduced‐order methodology (cFFR_RO) was kept as simple as...

article

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

Erwin Cabrera, Paul Mathews, Emiliya Mezhericher, Thomas G. Beach, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2018 > 1864 > 1 > 208-225

Extensive parenchymal and vascular Aβ deposits are pathological hallmarks of Alzheimer's disease (AD). Besides classic full-length peptides, biochemical analyses of brain deposits have revealed high degree of Aβ heterogeneity likely resulting from the action of multiple proteolytic enzymes. In spite of the numerous studies focusing in Aβ, the relevance of N- and C-terminal truncated species for AD...

article

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

Aram S. Modrek, Danielle Golub, Themasap Khan, Devin Bready, more

Cell Reports > 2017 > 21 > 5 > 1267-1280

Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into human neural stem cells (NSCs). These oncogenic hits blocked NSC differentiation, increased invasiveness in vivo, and led to a DNA methylation and transcriptional profile resembling IDH1 mutant...

article

Sealed accelerants facilitate epoxy asphalt concretes opening to traffic quickly

Mingyu Song, Rui Liang, Jingjing Deng, Yang Kang

Construction and Building Materials > 2017 > 147 > C > 1-8

Epoxy asphalt composites (EACs) have been recommended to be a prior choice to obtain long-life pavements. However, the present anhydrides-cured EACs have to be field-maintained in high summer for over 45days to achieve their ultimate performance. To be opened to traffic immediately, sealed accelerants, triggered by the compact pressure when paved, were employed to accelerate post-cure of EACs. Compared...

article

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

Zhifeng Huang, Yi Tan, Junlian Gu, Yang Liu, more

Cell Reports > 2017 > 20 > 7 > 1717-1728

The recent discovery of metabolic roles for fibroblast growth factor 1 (FGF1) in glucose homeostasis has expanded the functions of this classically known mitogen. To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple mutations (FGF1^ΔHBS) that diminished its ability to induce heparan sulfate (HS)-assisted FGF receptor (FGFR) dimerization...

chapter

Learning feature extractors for AMD classification in OCT using convolutional neural networks

Dafydd Ravenscroft, Jingjing Deng, Xianghua Xie, Louise Terry, more

2017 25th European Signal Processing Conference (EUSIPCO) > 51 - 55

2017 25th European Signal Processing Conference (EUSIPCO)

In this paper, we propose a two-step textural feature extraction method, which utilizes the feature learning ability of Convolutional Neural Networks (CNN) to extract a set of low level primitive filter kernels, and then generalizes the discriminative power by forming a histogram based descriptor. The proposed method is applied to a practical medical diagnosis problem of classifying different stages...

chapter

Nested Shallow CNN-Cascade for Face Detection in the Wild

Jingjing Deng, Xianghua Xie

2017 12th IEEE International Conference on Automatic Face & Gesture Recognition (FG 2017) > 165 - 172

2017 12th IEEE International Conference on Automatic Face & Gesture Recognition (FG 2017)

Face detection in the wild is a challenging vision problem due to large variations and unpredictable ambiguities commonly existed in real world images. Whilst introducing powerful but complex models is often computationally inefficient, using hand-crafted features is hence problematic. In this paper, we propose a nested CNN-cascade learning algorithm that adopts shallow neural network architectures...

article

Highly sensitive GQDs-MnO2 based assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase fluctuation: A biomarker for organophosphorus pesticides poisoning and management

Jingjing Deng, Dingkun Lu, Xiaolei Zhang, Guoyue Shi, more

Environmental Pollution > 2017 > 224 > C > 436-444

In this study, we demonstrated an assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase (AChE) fluctuation as a biomarker for organophosphorus pesticides (OPs) poisoning and management based on single layer MnO₂ nanosheets with graphene quantum dots (GQDs) as signal readout. Initially, the fluorescence of GQDs was quenched by MnO₂ nanosheets mainly due to the inner filter...

article

β‐cyclodextrin‐ionic liquid polymer based dynamically coating for simultaneous determination of tetracyclines by capillary electrophoresis

Chunyan Zhou, Jingjing Deng, Guoyue Shi, Tianshu Zhou

ELECTROPHORESIS > 38 > 7 > 1060 - 1067

Tetracyclines are a group of broad spectrum antibiotics widely used in animal husbandry to prevent and treat diseases. However, the improper use of tetracyclines may result in the presence of their residues in animal tissues or waste. Recently, great attention has been drawn towards the green solvents ionic liquids. Ionic liquids have been employed as a coating material to modify the electroosmotic...

chapter

Labeling subtle conversational interactions within the CONVERSE dataset

Michael Edwards, Jingjing Deng, Xianghua Xie

2017 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops) > 140 - 145

2017 IEEE International Conference on Pervasive Computing and Communications Workshops (PerCom Workshops)

The field of Human Action Recognition has expanded greatly in previous years, exploring actions and interactions between individuals via the use of appearance and depth based pose information. There are numerous datasets that display action classes composed of behaviors that are well defined by their key poses, such as ‘kicking’ and ‘punching’. The CONVERSE dataset presents conversational interaction...

article

Polyacrylic acid-coated cerium oxide nanoparticles: An oxidase mimic applied for colorimetric assay to organophosphorus pesticides

Shi-Xiang Zhang, Shi-Fan Xue, Jingjing Deng, Min Zhang, more

Biosensors and Bioelectronics > 2016 > 85 > C > 457-463

It is important and urgent to develop reliable and highly sensitive methods that can provide on-site and rapid detection of extensively used organophosphorus pesticides (OPs) for their neurotoxicity. In this study, we developed a novel colorimetric assay for the detection of OPs based on polyacrylic acid-coated cerium oxide nanoparticles (PAA-CeO₂) as an oxidase mimic and OPs as inhibitors to suppress...

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INFONA - science communication portal

Search results for: Jingjing Deng

Macrocyclic Encapsulation in a Non‐fused Tetrathiophene Acceptor for Efficient Organic Solar Cells with High Short‐Circuit Current Density

Macrocyclic Encapsulation in a Non‐fused Tetrathiophene Acceptor for Efficient Organic Solar Cells with High Short‐Circuit Current Density

Clinical application of metagenomic next‐generation sequencing technology in the diagnosis and treatment of pulmonary infection pathogens: A prospective single‐center study of 138 patients

Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Controlling Enamel Remineralization by Amyloid‐Like Amelogenin Mimics

Amyloid‐Like Rapid Surface Modification for Antifouling and In‐Depth Remineralization of Dentine Tubules to Treat Dental Hypersensitivity

Real-time moving pedestrian detection using contour features

A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

Estimating the accuracy of a reduced‐order model for the calculation of fractional flow reserve (FFR)

Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

Sealed accelerants facilitate epoxy asphalt concretes opening to traffic quickly

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

Learning feature extractors for AMD classification in OCT using convolutional neural networks

Nested Shallow CNN-Cascade for Face Detection in the Wild

Highly sensitive GQDs-MnO2 based assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase fluctuation: A biomarker for organophosphorus pesticides poisoning and management

β‐cyclodextrin‐ionic liquid polymer based dynamically coating for simultaneous determination of tetracyclines by capillary electrophoresis

Labeling subtle conversational interactions within the CONVERSE dataset

Polyacrylic acid-coated cerium oxide nanoparticles: An oxidase mimic applied for colorimetric assay to organophosphorus pesticides

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