Search results for: Dwaipayan Sen

Items from 1 to 20 out of 30 results

article

PET pyrolysis: Kinetics of a‐graphite

Zinnia Chowdhury, Sanjib Barma, Dwaipayan Sen, Aparna Ray Sarkar

Environmental Quality Management > 33 > 4 > 843 - 854

One of the primary issues nowadays is plastic waste management, where the low recycling rates and accumulation of waste plastic show an exponentially increasing trend with urbanization. Especially, the concern is high with the PET waste generated from food packaging industries. Thus, new technologies are required for waste refining. Pyrolysis is one such technique that will restrict the emission possibilities...

article

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

Katari Venkatesh, Shounak K. Ghosh, Madhubanti Mullick, Geetha Manivasagam, more

Cell and Tissue Research > 2019 > 377 > 2 > 125-151

Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites of damage which can generate both neuronal and glial population has gained impact in terms of recuperation upon infliction with spinal cord injury. In spite of the fact that a copious number of pre-clinical studies...

article

Regulation of Cardiomyocyte Differentiation, Angiogenesis, and Inflammation by the Delta Opioid Signaling in Human Mesenchymal Stem Cells

L. Vinod Kumar Reddy, Dwaipayan Sen

Regenerative Engineering and Translational Medicine > 2019 > 5 > 3 > 252-262

Background Lack of angiogenesis, inflammation, and low differentiation of MSCs upon transplantation to ischemic site are major drawbacks in cell therapies for myocardial tissue regeneration. To overcome these problems, this study aimed to increase the angiogenesis, anti-inflammation, and differentiation of human umbilical cord MSCs (hMSCs) into cardiomyocytes by activating the delta opioid pathway...

article

Amelioration of Acetaminophen-Induced Liver Injury Via Delta Opioid Receptor–Activated Human Mesenchymal Stem Cells—an In Vivo Approach

Madhubanti Mullick, Srijita Banerjee, Dwaipayan Sen

Regenerative Engineering and Translational Medicine > 2019 > 5 > 3 > 263-269

Background Liver injury poses to be a prevalent and persistent problem at a global scale and liver transplantation using umbilical cord blood–borne human mesenchymal stem cells (hMSCs) being the frequent respite to overcome it. Although there has been a plethora of advancements in liver transplantation studies, failures of a successful transplant remain difficult to evade, majorly due to lack of hMSC...

article

Infectivity of adeno-associated virus serotypes in mouse testis

Santhanasabapathy Rajasekaran, Jayashree Thatte, Jayaprakash Periasamy, Alok Javali, more

BMC Biotechnology > 2018 > 18 > 1 > 1-9

Background Recombinant adeno-associated viruses (AAVs) are emerging as favoured transgene delivery vectors for both research applications and gene therapy. In this context, a thorough investigation of the potential of various AAV serotypes to transduce specific cell types is valuable. Here, we rigorously tested the infectivity of a number of AAV serotypes in murine testis by direct testicular injection...

article

Enumeration of monosugars’ inhibition characteristics on the kinetics of enzymatic hydrolysis of cellulose

Dibyajyoti Haldar, Kalyan Gayen, Dwaipayan Sen

Process Biochemistry > 2018 > 72 > C > 130-136

A kinetic model based on Michaelis-Menten assumptions is developed here for enzymatic hydrolysis of cellulose using cellulase enzyme derived from Trichoderma reesei. Further, to assess the inhibition of enzyme and the nature of inhibition by different sugars (glucose, galactose, mannose, xylose and cellobiose) the primary kinetic model is modified with the inhibition kinetics. The enzymatic reaction...

article

The delta opioid peptide D‐Alanine 2, Leucine 5 Enkephaline (DADLE)‐induces neuroprotection through cross‐talk between the UPR and pro‐survival MAPK‐NGF‐Bcl2 signaling pathways via modulation of several micro‐RNAs in SH‐SY5Y cells subjected to ER stress

Erfath Thanjeem Begum Moghal, Katari Venkatesh, Dwaipayan Sen

Cell Biology International > 42 > 5 > 543 - 569

Parkinson's disease (PD) is the second most progressive neurodegenerative disease characterized by the loss of dopaminergic neurons and accumulation of misfolded proteins in endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR). In the present study, we aimed to determine the potential survival effect of the delta opioid neuro‐peptide D‐Alanine 2, Leucine 5 Enkephaline...

article

The Delta Opioid Peptide DADLE Represses Hypoxia-Reperfusion Mimicked Stress Mediated Apoptotic Cell Death in Human Mesenchymal Stem Cells in Part by Downregulating the Unfolded Protein Response and ROS along with Enhanced Anti-Inflammatory Effect

Madhubanti Mullick, Dwaipayan Sen

Stem Cell Reviews and Reports > 2018 > 14 > 4 > 558-573

Hypoxia-reperfusion (H/R) emblems a plethora of pathological conditions which is potent in contributing to the adversities encountered by human mesenchymal stem cells (hMSCs) in post-transplant microenvironment, resulting in transplant failure. D-Alanine 2, Leucine 5 Enkephaline (DADLE)-mediated delta opioid receptor (DOR) activation is well-known for its recuperative properties in different cell...

article

Progress of Regenerative Therapy in Orthopedics

Pearlin, Sunita Nayak, Geetha Manivasagam, Dwaipayan Sen

Current Osteoporosis Reports > 2018 > 16 > 2 > 169-181

Purpose of Review To conduct a thorough appraisal of recent and inventive advances in the field of bone tissue engineering using biomaterials, cell-based research, along with the incorporation of biomimetic properties using surface modification of scaffolds. Recent Findings This paper will provide an overview on different biomaterials and emerging techniques involved in the fabrication of scaffolds,...

article

Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?

Rutika Raina, Dwaipayan Sen

Neurochemistry International > 2018 > 112 > C > 206-218

The progressive loss of structure and function of neurons leads to neurodegenerative processes which become the causative reason for various neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD) etc. These diseases are multifactorial in nature but they have been seen to possess similar causative agents to a certain extent. Oxidative Stress (OS) has been identified as...

article

DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to ‘serum free’ apoptotic condition in part via the DOR/PI3K/AKT pathway

L. Vinod Kumar Reddy, Dwaipayan Sen

Life Sciences > 2017 > 191 > C > 195-204

Nutritional deprivation and inflammation-rich zones are the major causative reasons for poor survivability of transplanted mesenchymal stem cells (MSCs). Therefore in the present study, we demonstrated the cytoprotective and anti-inflammatory effects of activated delta (δ)-opioid receptor (DOR) with synthetic peptide [D-Ala², D-Leu⁵]-enkephalin (DADLE) treatment on human MSCs cultured in serum-starved...

chapter

Pose invariant thermal face recognition using patch-wise self-similarity features

Sandip Joardar, Dwaipayan Sen, Diparnab Sen, Arnab Sanyal, more

2017 Third International Conference on Research in Computational Intelligence and Communication Networks (ICRCICN) > 203 - 207

2017 Third International Conference on Research in Computational Intelligence and Communication Networks (ICRCICN)

This paper presents a Pose Invariant Face Recognition algorithm for pose-variance in face databases, which is one of the toughest challenges of any face recognition based biometrics, using a novel feature extraction technique. The feature extraction of the raw images is based upon a novel patch-wise self-similarity measure within an image. The algorithm has been tested upon a Far-infrared (FIR) imaging...

article

d-Alanine 2, Leucine 5 Enkephaline (DADLE)-mediated DOR activation augments human hUCB-BFs viability subjected to oxidative stress via attenuation of the UPR

Madhubanti Mullick, Katari Venkatesh, Dwaipayan Sen

Stem Cell Research > 2017 > 22 > C > 20-28

Human mesenchymal stem cells (hMSCs) although being potent in repairing injured or ischemic tissues, their success regarding tissue-regenerative approaches are hindered by the paucity in their viability. The elevated levels of reactive oxygen species (ROS) in damaged sites provoke the pernicious effects of donor MSC survival. In the present study, the effect of delta-opioid receptor (DOR) activation...

article

Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases

Abesh Bera, Dwaipayan Sen

Heart Failure Reviews > 2017 > 22 > 6 > 795-823

Cardiovascular diseases pose a unique threat to global mortality because it presents as one of the most diverse conglomerations of pathophysiological conditions that can create significant casualty even without straying into its collateral damage. This puts them right beside obesity and cancer in terms of severity. Their pervasive nature and high prevalence prompted biologists to seek newer prophylactic...

article

Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

Akshaya Krishnagopal, Aakash Reddy, Dwaipayan Sen

The Journal of Gene Medicine > 19 > 5 > n/a - n/a

This review concisely recapitulates the different existing modes of stent‐mediated gene/drug delivery, their considerable advancement in clinical trials and a rationale for other merging new technologies such as nanotechnology and microRNA‐based therapeutics, in addition to addressing the limitations in each of these perpetual stent platforms. Over the past decade, stent‐mediated gene/drug delivery...

article

MicroRNAs in Parkinson’s disease

Abhishek Singh, Dwaipayan Sen

Experimental Brain Research > 2017 > 235 > 8 > 2359-2374

Parkinson’s disease is the second most common neurodegenerative disease commonly affecting the older population. Loss of dopaminergic neurons in the substantia nigra of brain leads to impairment of motor activities as well as cognitive defects. There are many underlying causes to this disease, both genetic and epigenetic, which are yet to be fully explored. Non-coding RNAs are significant part of...

article

Development of Spectrophotometric Method for the Analysis of Multi-component Carbohydrate Mixture of Different Moieties

Dibyajyoti Haldar, Dwaipayan Sen, Kalyan Gayen

Applied Biochemistry and Biotechnology > 2017 > 181 > 4 > 1416-1434

Present study is a critical analysis and subsequent development of an analytical tool to measure the total sugar concentration in a carbohydrate mixture comprising both hexose and pentose. For this purpose, individual sugars were measured and standardized with anthrone reagent prepared in an ice-cold 98 % sulphuric acid followed by 3 min of boiling. Furthermore, regression analysis was performed after...

article

High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity

Yesupatham Sathishkumar, Chandran Krishnaraj, Kalyanaraman Rajagopal, Dwaipayan Sen, more

Bioprocess and Biosystems Engineering > 2016 > 39 > 2 > 223-231

In this study, the transcriptional alterations in Penicillium chrysogenum under simulated microgravity conditions were analyzed for the first time using an RNA-Seq method. The increasing plethora of eukaryotic microbial flora inside the spaceship demands the basic understanding of fungal biology in the absence of gravity vector. Penicillium species are second most dominant fungal contaminant in International...

article

Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010–2015)

Aastha Singh, Abhishek Singh, Dwaipayan Sen

Stem Cell Research & Therapy > 2016 > 7 > 1 > 1-25

Mesenchymal stem cells have been used for cardiovascular regenerative therapy for decades. These cells have been established as one of the potential therapeutic agents, following several tests in animal models and clinical trials. In the process, various sources of mesenchymal stem cells have been identified which help in cardiac regeneration by either revitalizing the cardiac stem cells or revascularizing...

article

Microgravity biosynthesized penicillin loaded electrospun polyurethane–dextran nanofibrous mats for biomedical applications

Yesupatham Sathish Kumar, Afeesh Rajan Unnithan, Dwaipayan Sen, Cheol Sang Kim, more

Colloids and Surfaces A: Physicochemical and Engineering Aspects > 2015 > 477 > Complete > 77-83

Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers onto a target substrate. Nanofiber possess the characteristic features of high length-to-diameter ratio and specific surface areas, enabling it to be used for protective clothing, filter, antibacterial membrane, reinforced composite, and tissue engineering. We have adopted a method of direct...

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INFONA - science communication portal

Search results for: Dwaipayan Sen

PET pyrolysis: Kinetics of a‐graphite

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

Regulation of Cardiomyocyte Differentiation, Angiogenesis, and Inflammation by the Delta Opioid Signaling in Human Mesenchymal Stem Cells

Amelioration of Acetaminophen-Induced Liver Injury Via Delta Opioid Receptor–Activated Human Mesenchymal Stem Cells—an In Vivo Approach

Infectivity of adeno-associated virus serotypes in mouse testis

Enumeration of monosugars’ inhibition characteristics on the kinetics of enzymatic hydrolysis of cellulose

The delta opioid peptide D‐Alanine 2, Leucine 5 Enkephaline (DADLE)‐induces neuroprotection through cross‐talk between the UPR and pro‐survival MAPK‐NGF‐Bcl2 signaling pathways via modulation of several micro‐RNAs in SH‐SY5Y cells subjected to ER stress

The Delta Opioid Peptide DADLE Represses Hypoxia-Reperfusion Mimicked Stress Mediated Apoptotic Cell Death in Human Mesenchymal Stem Cells in Part by Downregulating the Unfolded Protein Response and ROS along with Enhanced Anti-Inflammatory Effect

Progress of Regenerative Therapy in Orthopedics

Can crosstalk between DOR and PARP reduce oxidative stress mediated neurodegeneration?

DADLE enhances viability and anti-inflammatory effect of human MSCs subjected to ‘serum free’ apoptotic condition in part via the DOR/PI3K/AKT pathway

Pose invariant thermal face recognition using patch-wise self-similarity features

d-Alanine 2, Leucine 5 Enkephaline (DADLE)-mediated DOR activation augments human hUCB-BFs viability subjected to oxidative stress via attenuation of the UPR

Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases

Stent‐mediated gene and drug delivery for cardiovascular disease and cancer: A brief insight

MicroRNAs in Parkinson’s disease

Development of Spectrophotometric Method for the Analysis of Multi-component Carbohydrate Mixture of Different Moieties

High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity

Mesenchymal stem cells in cardiac regeneration: a detailed progress report of the last 6 years (2010–2015)

Microgravity biosynthesized penicillin loaded electrospun polyurethane–dextran nanofibrous mats for biomedical applications

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