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This work is devoted to mathematical modeling of spent dialysate regeneration by sorption. A method for mathematical modeling of sorption of such metabolites as creatinine and uric acid in the sorption columns of a wear able artificial kidney is suggested. The method was tested with different types of activated carbon used in sorption columns. The root-mean-square criterion did not exceed 630 μmol/L.
Regeneration of spent dialysate using enzymatic and sorption methods is discussed. Use of urease enzyme immobilized on a solid carrier is suggested. A complex sorption column implementing these methods was tested. Prospects for its use in a regeneration system of a wearable artificial kidney apparatus are discussed.