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Halobacterium salinarum is an extreme halophile archaeon with an absolute requirement for a multimolar salt environment. It accumulates molar concentrations of KCl in the cytosol to counterbalance the external osmotic pressure imposed by the molar NaCl. As a consequence, cytosolic proteins are permanently exposed to low water activity and highly ionic conditions. In non-adapted systems, such conditions...
Non‐technical summary The response to stress is orchestrated by parvocellular neuroendocrine cells in the paraventricular nucleus of the hypothalamus. These cells integrate synaptic information from a number of brain regions and release hormone, yet little is known about the basic rules of synaptic communication at glutamate synapses that provide the dominant excitatory input to these cells. Here...
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