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Understanding central mechanisms underlying drug-induced toxicity plays a crucial role in drug development and drug safety. However, a translation of cellular in vitro findings to an actual in vivo context remains challenging. Here, physiologically based pharmacokinetic (PBPK) modeling was used for in vivo contextualization of in vitro toxicity data (PICD) to quantitatively predict in vivo drug response...
Human physiology covers multiple levels of biological organization. For a mechanistic understanding of diseases and a rational development of targeted therapeutic strategies, a simultaneous consideration of processes at the cellular scale and at the whole-body level is desirable. We here discuss how metabolic network models can be integrated into physiology-based pharmacokinetic models at organism...
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