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Aims/hypothesis Women with a history of gestational diabetes mellitus (GDM) have raised liver triacylglycerol. Restriction of energy intake in type 2 diabetes can normalise glucose control and liver triacylglycerol concentration but it is not known whether similar benefits could be achieved in GDM. The aim of this work was to examine liver triacylglycerol accumulation in women with GDM and the effect...
The efficiency of glucose and insulin control on glucose production (EGP) plays an important role in glucose homeostasis and its derangement in diabetes. Therefore the ability to accurately quantify indices of the individual role of glucose (GEL) and insulin (SIL) in the suppression of EGP would allow to improve the understanding of liver metabolism. Measuring these indices by minimal modelling of...
A simulation model of the glucose-insulin system in the postprandial state can be useful for studying the pathophysiology of diabetes. Here we present a new simulation model which describes the physiological events which occur after a meal, by employing the quantitative knowledge which has become available in recent years. Model parameters were set to fit data of 204 normal subjects which underwent...
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