Search results for: Thomas Harder

Items from 1 to 20 out of 48 results

article

Efficient $t_{0}$ ‐year risk regression using the logistic model

Torben Martinussen, Thomas Harder Scheike

Scandinavian Journal of Statistics > 50 > 4 > 1919 - 1932

In some clinical studies patient survival beyond a specific point in time,

t_{0}

, say, may be of special interest as it may for instance indicate patient cure. To analyze the

t_{0}

‐year risk for such patients may be accomplished using logistic regression with appropriate weights (IPWCC) that may further be augmented (AIPWCC) to improve efficiency. In this paper, we derive the most...

article

Corrosion challenges towards a sustainable society

Roman Bender, Damien Féron, Douglas Mills, Stefan Ritter, more

Materials and Corrosion > 73 > 11 > 1730 - 1751

A global transition towards more sustainable, affordable and reliable energy systems is being stimulated by the Paris Agreement and the United Nation's 2030 Agenda for Sustainable Development. This poses a challenge for the corrosion industry, as building climate‐resilient energy systems and infrastructures brings with it a long‐term direction, so as a result the long‐term behaviour of structural...

article

On the estimation of average treatment effects with right‐censored time to event outcome and competing risks

Brice Maxime Hugues Ozenne, Thomas Harder Scheike, Laila Stærk, Thomas Alexander Gerds

Biometrical Journal > 62 > 3 > 751 - 763

We are interested in the estimation of average treatment effects based on right‐censored data of an observational study. We focus on causal inference of differences between t‐year absolute event risks in a situation with competing risks. We derive doubly robust estimation equations and implement estimators for the nuisance parameters based on working regression models for the outcome, censoring, and...

article

Die neue Standardvorgehensweise der Ständigen Impfkommission (STIKO): Entstehung, Struktur und Umsetzung

Thomas Harder, Judith Koch, Rüdiger von Kries, Ole Wichmann

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz > 2019 > 62 > 4 > 392-399

In Deutschland gibt die Ständige Impfkommission (STIKO) Empfehlungen zur Durchführung von Schutzimpfungen und zur Durchführung anderer Maßnahmen der spezifischen Prophylaxe übertragbarer Krankheiten. Die Umsetzung dieser Empfehlungen wird durch Mythen und Mutmaßungen bis hin zu Verschwörungstheorien in der öffentlichen Diskussion zu Impfungen gefährdet. Evidenz und Transparenz der Empfehlungen können...

article

Sepsis prediction during outbreaks at neonatal intensive care units through body surface screening for Gram-negative bacteria: systematic review and meta-analysis

Thomas Harder, Sebastian Haller, Tim Eckmanns, Juliane Seidel

BMC Research Notes > 2018 > 11 > 1 > 1-5

Objective This systematic review focusses on the prognostic accuracy of neonatal body surface screening during outbreaks caused by Gram-negative bacteria for prediction of sepsis. In a previous systematic review we reported that only limited evidence of very low quality exists regarding the predictive value of this screening under routine conditions. We aimed to investigate whether this is different...

article

Die STIKO empfiehlt die HPV-Impfung jetzt auch für Jungen

Stefanie J. Klug, Marianne van der Sande, Martin Terhardt, Fred Zepp, more

Der Urologe > 2018 > 57 > 11 > 1346-1350

Aus Gründen der besseren Lesbarkeit wird in diesem Beitrag überwiegend das generische Maskulinum verwendet. Dies impliziert immer beide Formen, schließt also die weibliche Form mit ein.

article

Background paper for the recommendation of HPV vaccination for boys in Germany

Anja Takla, Miriam Wiese-Posselt, Thomas Harder, Jörg J. Meerpohl, more

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz > 2018 > 61 > 9 > 1170-1186

Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00103-018-2791-2) contains supplementary material, which is available to authorized users.

article

Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review

Thomas Harder, Ole Wichmann, Stefanie J. Klug, Marianne A. B. van der Sande, more

BMC Medicine > 2018 > 16 > 1 > 1-14

Background Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also advocated, but systematic reviews on efficacy and safety in males are lacking. Methods We performed a systematic review on the efficacy, effectiveness and safety of HPV vaccination...

article

Predicted vs observed effectiveness of outer membrane vesicle (OMV) vaccines against meningococcal serogroup B disease: Systematic review

Thomas Harder, Judith Koch, Ole Wichmann, Wiebke Hellenbrand

Journal of Infection > 2017 > 75 > 2 > 81-94

Human serum bactericidal antibody levels (hSBA) are commonly used as an immune correlate of protection after vaccination against meningococcal disease. We performed a systematic review of how well this marker correlates with protection induced by outer membrane vesicle (OMV) vaccines against meningococcal B (MenB) disease.To compare vaccine effectiveness (VE) of OMV vaccines against MenB predicted...

article

Effectiveness, immunogenicity and safety of 23-valent pneumococcal polysaccharide vaccine revaccinations in the elderly: a systematic review

Cornelius Remschmidt, Thomas Harder, Ole Wichmann, Christian Bogdan, more

BMC Infectious Diseases > 2016 > 16 > 1 > 1-12

Background In many industrialized countries routine vaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV-23) is recommended to prevent pneumococcal disease in the elderly. However, vaccine-induced immunity wanes after a few years, and there are controversies around revaccination with PPSV-23. Here, we systematically assessed the effectiveness and safety of PPSV-23 revaccination...

article

Hintergrundpapier der STIKO: Evaluation der bestehenden Influenzaimpfempfehlung für Indikationsgruppen und für Senioren (Standardimpfung ab 60 Jahren)

Cornelius Remschmidt, Thomas Harder, Ole Wichmann, Edeltraut Garbe, more

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz > 2016 > 59 > 12 > 1606-1622

Zusatzmaterial online In der Online-Version dieses Artikels (doi: 10.1007/s00103-016-2467-8 ) finden Sie den Anhang zum Hintergrundpapier der STIKO.

article

Use of existing systematic reviews for evidence assessments in infectious disease prevention: a comparative case study

Thomas Harder, Cornelius Remschmidt, Sebastian Haller, Tim Eckmanns, more

Systematic Reviews > 2016 > 5 > 1 > 1-13

Background Given limited resources and time constraints, the use of existing systematic reviews (SR) for the development of evidence-based public health recommendations has become increasingly important. Recently, a five-step approach for identifying, analyzing, appraising and using existing SRs based on recent guidance by the US Agency for Healthcare Research and Quality (AHRQ) was proposed within...

article

Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration in twin pregnancies

Thorsten Braun, Alexander Weichert, Hannah C. Gil, Deborah M. Sloboda, more

International Journal of Gynecology & Obstetrics > 2016 > 134 > 3 > 329-335

To investigate effects of betamethasone on fetal growth and neonatal outcomes in twins.A retrospective cohort study was conducted of twins delivered at one center in Berlin, Germany, between 1993 and 2011. The betamethasone group included twin pregnancies with preterm labor, cervical shortening, preterm premature rupture of membranes, or vaginal bleeding, and exposure to betamethasone between 23⁺⁵...

article

Erratum to: ‘Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children’

Gerhard Grevers, Susanne Wiedemann, Jan-Christof Bohn, Rolf-Werner Blasius, more

BMC Infectious Diseases > 2016 > 16 > 1 > 1-1

article

Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration

Thorsten Braun, Deborah M. Sloboda, Boris Tutschek, Thomas Harder, more

International Journal of Gynecology and Obstetrics > 2015 > 130 > 1 > 64-69

To determine the effects of betamethasone on fetal growth and neonatal outcomes.A retrospective cohort study was performed of deliveries that occurred at Charité University Hospital Berlin, Germany, between January 1996 and December 2008. The betamethasone group included women with preterm labor and symptomatic contractions, cervical insufficiency, preterm premature rupture of membranes, or vaginal...

article

Towards a framework for evaluating and grading evidence in public health

Thomas Harder, Muna Abu Sin, Xavier Bosch-Capblanch, Bruno Coignard, more

Health policy > 2015 > 119 > 6 > 732-736

The Project on a Framework for Rating Evidence in Public Health (PRECEPT) is an international collaboration of public health institutes and universities which has been funded by the European Centre for Disease Prevention and Control (ECDC) since 2012. Main objective is to define a framework for evaluating and grading evidence in the field of public health, with particular focus on infectious disease...

article

Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: a systematic review

Cornelius Remschmidt, Ole Wichmann, Thomas Harder

BMC Infectious Diseases > 2015 > 15 > 1 > 1-15

Background Evidence on influenza vaccine effectiveness (VE) is commonly derived from observational studies. However, these studies are prone to confounding by indication and healthy vaccinee bias. We aimed to systematically investigate these two forms of confounding/bias. Methods Systematic review of observational studies reporting influenza VE and indicators for bias and confounding. We assessed...

article

Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis

Cornelius Remschmidt, Ole Wichmann, Thomas Harder

BMC Medicine > 2015 > 13 > 1 > 1-11

Background Patients with diabetes are at increased risk of severe influenza disease; influenza vaccination for these patients is therefore recommended by the World Health Organization and several National Immunization Technical Advisory Groups. However, no systematic review has evaluated the effects of influenza vaccines for patients with diabetes. Methods We conducted a systematic review...

article

Background Paper for the update of meningococcal vaccination recommendations in Germany: use of the serogroup B vaccine in persons at increased risk for meningococcal disease

Wiebke Hellenbrand, Judith Koch, Thomas Harder, Christian Bogdan, more

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz > 2015 > 58 > 11-12 > 1314-1343

In December 2013 Bexsero® became available in Germany for vaccination against serogroup B meningococci (MenB). In August 2015 the German Standing Committee on Vaccination (STIKO) endorsed a recommendation for use of this vaccine in persons at increased risk of invasive meningococcal disease (IMD). This background paper summarizes the evidence underlying the recommendation. Bexsero® is based on surface...

article

Influenza vaccination in HIV-infected individuals: Systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness and safety

Cornelius Remschmidt, Ole Wichmann, Thomas Harder

Vaccine > 2014 > 32 > 43 > 5585-5592

Influenza infection in HIV-infected individuals is associated with increased severity of illness. We performed a systematic review of the available evidence on efficacy, effectiveness and safety of seasonal influenza vaccination in HIV-infected individuals.Systematic review, meta-analysis and assessment of evidence quality.Using a previous systematic review as starting point, we searched MEDLINE,...

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INFONA - science communication portal

Search results for: Thomas Harder

Efficient $t_{0}$ ‐year risk regression using the logistic model

Corrosion challenges towards a sustainable society

On the estimation of average treatment effects with right‐censored time to event outcome and competing risks

Die neue Standardvorgehensweise der Ständigen Impfkommission (STIKO): Entstehung, Struktur und Umsetzung

Sepsis prediction during outbreaks at neonatal intensive care units through body surface screening for Gram-negative bacteria: systematic review and meta-analysis

Die STIKO empfiehlt die HPV-Impfung jetzt auch für Jungen

Background paper for the recommendation of HPV vaccination for boys in Germany

Efficacy, effectiveness and safety of vaccination against human papillomavirus in males: a systematic review

Predicted vs observed effectiveness of outer membrane vesicle (OMV) vaccines against meningococcal serogroup B disease: Systematic review

Effectiveness, immunogenicity and safety of 23-valent pneumococcal polysaccharide vaccine revaccinations in the elderly: a systematic review

Hintergrundpapier der STIKO: Evaluation der bestehenden Influenzaimpfempfehlung für Indikationsgruppen und für Senioren (Standardimpfung ab 60 Jahren)

Use of existing systematic reviews for evidence assessments in infectious disease prevention: a comparative case study

Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration in twin pregnancies

Erratum to: ‘Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children’

Fetal and neonatal outcomes after term and preterm delivery following betamethasone administration

Towards a framework for evaluating and grading evidence in public health

Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: a systematic review

Vaccines for the prevention of seasonal influenza in patients with diabetes: systematic review and meta-analysis

Background Paper for the update of meningococcal vaccination recommendations in Germany: use of the serogroup B vaccine in persons at increased risk for meningococcal disease

Influenza vaccination in HIV-infected individuals: Systematic review and assessment of quality of evidence related to vaccine efficacy, effectiveness and safety

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