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Purpose Evaluation of potential grafts to improve upon current strategies for abdominal wall (AW) repair in small animal models typically involves mechanical testing using methods that currently are inadequate to assess physiologically relevant parameters. This study introduces burst inflation testing as a more relevant assessment of the mechanical integrity of the AW compared to traditional tensile...
Introduction: LPS-Binding-Protein (LBP), a class I acute phase protein, is capable of enhancing inflammatory cytokine production in response to LPS (lipopolysaccharide, endotoxin). It also functions as an opsonin for Gram-negative bacteria and reduces by 10,000-fold the concentration of neutrophil derived BPI (bactericidal permeability increasing protein) necessary to kill Gram-negative...
Adult skeletal muscle has the striking ability to repair and regenerate itself after injury. This would not be possible without satellite cells, a subpopulation of cells existing at the margin of the myofiber. Under most conditions, satellite cells are quiescent, but they are activated in response to trauma, enabling them to guide skeletal muscle regeneration. In degenerative skeletal muscle states,...
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