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Idiopathic REM sleep behavior disorder (RBD) is a parasomnia characterized by the loss of physiological atonia of skeletal muscles during dream sleep. This leads to enactment of dream content with nocturnal behavior such as flailing of the arms, kicking and/or vocalization (Boeve, 2010). RBD may be the initial manifestation of neurodegenerative α-synucleinopathies (Parkinson’s disease [PD], Parkinson’s...
Motor disability in MS is commonly assessed by the Expanded Disability Status Scale (EDSS). Categorical rating scales are limited by subjective error and inter-rater variability. Therefore, objective and quantitative measures of motor disability may be useful to supplement the EDSS in the setting of clinical trials. It was previously shown that grip-force-variability (GFV) is increased in MS. We hypothesized...
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