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A new amide, N-trans-sinapoylmethoxytyramine (1), along with three known amides (2–4) and two known flavonol 3-O-rhamnosides (5 and 6), were isolated from the leaves and twigs of Litsea auriculata. The structures of the isolated compounds (1–6) were characterized on the basis of spectroscopic analyses, and their cytotoxic activity against HeLa cells was estimated.