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Background:The cytotoxic agent bendamustine combines apurine-like benzimidazol and alkylating nitrogen mustard group. The clinicallytolerated dose for single bolus bendamustine is 215 mg/m2, forfractionated therapy on four consecutive days 85 mg/m2. The maximumtolerated dose of a day 1 and 8 (q4w) 30 min infusion schedule was recentlyfound to be 160 mg/m2, mouth dryness and fatigue weredose-limiting...
The effects of intensification in dairy cattle upon ecologically harmful emissions was investigated using a theoretical model of change in the traits of a dairy cattle population under selection. The demand for milk by the consumer was assumed to be a constant. Therefore, an increase in milk yield per cow and per year would lead to a reduced dairy cattle population with a lowered capacity for beef...
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