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Cellular heterogeneity is a distinctive feature of high-grade gliomas [1]. What are the cellular mechanisms that give rise to the collection of cell types that comprise glioblastoma multiforme? According to the clonal evolution model of tumor heterogeneity (also known as the stochastic model), tumor initiation occurs by an induced change in a single previously normal cell (Fig. 3.1a) [2]. This neoplastic...
The sequential appearance of neurons and glia in the vertebrate central nervous system may be governed by competition between growth factor signaling pathways and downstream transcription factors. In cortical progenitor cell cultures, the proneural basic helix-loop-helix transcription factor Ngn1 suppresses formation of astrocytes by sequestering coactivator proteins that are required by signal transducers...
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