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Background. The INK4a-ARF (CDKN2A) locus, located on chromosome 9p21, encodes two functionally distinct tumor suppressor genes, p14ARF and p16INK4a, that play active roles in the p53 and Rb tumor suppressive pathways, respectively. We analyzed the alterations of p14ARF, p16INK4a and p53 to study the contribution of each pathway in tumorigenesis of 29 patients with primary and consecutive (second primary)...
Background. The INK4a-ARF (CDKN2A) locus, located on chromosome 9p21, encodes two functionally distinct tumor suppressor genes, p14ARF and p16INK4a, that play active roles in the p53 and Rb tumor suppressive pathways, respectively. We analyzed the alterations of p14ARF, p16INK4a and p53 to study the contribution of each pathway in tumorigenesis of 29 patients with primary and consecutive (second primary)...
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