Search results for: K. D. Praliev

Items from 1 to 20 out of 21 results

article

Synthesis of Monosubstituted Purpurins and Their Biological Activity

T. V. Kharlamova, R. B. Seidakhmetova, K. D. Praliev

Chemistry of Natural Compounds > 2019 > 55 > 4 > 622-625

Products were obtained from acylation of 1,2,4-trihydroxy-9,10-anthraquinone (purpurin) by saturated cyclic carboxylic acid chlorides. The compositions and structures of the monosubstituted compounds were confirmed by elemental analysis and IR and PMR spectroscopy. The cytotoxicities of the derivatives were evaluated in an Artemia salina Leach brine shrimp test.

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Supramolecular inclusion complexes of β-cyclodextrin with 4-(acyloxy)-4-(cyclopropylethynyl)-1-(2-ethoxyethyl)piperidines

T. M. Seilkhanov, T. K. Iskakova, S. S. Zhumakova, T. G. Bimurzayeva, more

Russian Journal of General Chemistry > 2017 > 87 > 2 > 270-275

4-Acyloxy-4-(cyclopropylethynyl)-1-(2-ethoxyethyl)piperidines have been synthesized by reaction of 1-(2-ethoxyethyl)piperidin-4-one with cyclopropylacetylene and subsequent acylation of intermediate 4-(cyclopropylethynyl)piperidin-4-ol. The resulting esters react with β-cyclodextrin to give supramolecular inclusion complexes. The complexation is accompanied by inclusion of the N-ethoxyethyl fragment...

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The structure and pharmacological properties of the 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine inclusion complex with β-cyclodextrin

R. A. Sharipov, K. S. Sharapov, U. S. Kemelbekov, V. A. Volynkin, more

Journal of Inclusion Phenomena and Macrocyclic Chemistry > 2017 > 87 > 1-2 > 141-148

Inclusion complex of 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine with β-cyclodextrin was synthesized. Composition (1:2) and the structure of the complex were confirmed by NMR spectroscopy and thermal analysis. The results of pharmacological studies showed that the compound is of interest for in-depth testing, because of its deeper and more prolonged conduction anaesthesia, terminal (superficial)...

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Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine

G. M. Pichkhadze, G. S. Smagulova, D. M. Kadyrova, K. D. Praliev, more

Pharmaceutical Chemistry Journal > 2016 > 50 > 9 > 600-602

Results from studies of the local anesthetic activity of LAS-54 [4-(benzoyloxy)-3-butoxypiperidinium chloride] (synthesized at the Laboratory of the Chemistry of Synthetic and Natural Drugs, Bekturov Institute of Chemical Sciences) in combination with epinephrine are presented. It was found that joint application of the vasoconstrictor with LAS-54, especially at low concentrations, prolonged infiltration,...

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Investigation of supramolecular inclusion complexes with β-cyclodextrin of 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-hydroxypiperidine and 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-benzoyloxypiperidine oxalate by NMR spectroscopy

T. M. Seilkhanov, L. A. Nazarenko, N. N. Poplavskii, O. T. Seilkhanov, more

Russian Journal of General Chemistry > 2016 > 86 > 1 > 110-115

A comparative analysis of ¹H and ¹³C NMR spectra of 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-hydroxypiperidine, 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-benzoyloxypiperidine oxalate and their inclusion complexes with β-cyclodextrin was performed. The differences in values of chemical shifts of ¹H and ¹³C nuclei of the substrates and the receptor in the inclusion complexes were determined. It was found that...

article

Synthesis and Myelostimulatory Activity of a Number of 3,7-Diazabicyclo[3.3.1]Nonane Derivatives

K. D. Praliev, T. K. Iskakova, L. K. Baktybaeva, A. E. Malmakova

Pharmaceutical Chemistry Journal > 2015 > 49 > 5 > 292-295

Mannich condensation was used to synthesize new bispidinones, Wolff-Kishner reduction of which produced the corresponding bispidanes. ¹H NMR spectroscopy studies showed that these existed in the double chair conformation. The myelostimulatory activity of the compounds synthesized here was assessed.

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NMR study of supramolecular inclusion complexes of 7-[2-(morpholin-4-yl)ethyl]-3-(2-ethoxyethyl)-3,7-diazabicyclo[3.3.1]nonane with cyclodextrins

T. M. Seilkhanov, L. A. Nazarenko, N. N. Poplavskii, O. T. Seilkhanov, more

Russian Journal of General Chemistry > 2015 > 85 > 5 > 1098-1102

Structures of 7-[2-(morpholin-4-yl)ethyl]-3-(2-ethoxyethyl)-3,7-diazabicyclo[3.3.1]nonane and its inclusion complexes with α-, β-, and γ-cyclodextrins have been studied by ¹H, ¹³C, COSY, and HMQC NMR spectroscopy. The complexes are formed via entering of one morpholine fragment of the substrate into the inner sphere of a receptor molecule.

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Preparation of an Inclusion Complex of 1-(3-n-butoxypropyl)-4-vinylacetylen-4-benzoyloxypiperidine with B-cyclodextrin and its Local Anesthetic Activity

G. M. Kaldybekova, U. S. Kemel’bekov, A. A. Abdildanova, K. D. Praliev, more

Pharmaceutical Chemistry Journal > 2014 > 48 > 3 > 196-200

Complex formation of 1-(3-n-butoxypropyl)-4-vinylacetylene-4-benzoyloxypiperidine with β-cyclodextrin was studied by NMR spectroscopy. The structural characteristics and composition (1:2) of the resulting inclusion complex of 1-(3-n-butoxypropyl)-4-vinylacetylene-4-benzoyloxypiperidine with β-cyclodextrin in aqueous solution were identified. The local anesthetic activity of the resulting preparation...

article

Local anesthetic activity of new amidoxime derivatives

L. A. Kayukova, K. D. Praliev, A. L. Akhelova, U. S. Kemel’bekov, more

Pharmaceutical Chemistry Journal > 2011 > 45 > 8 > 468-471

Three series of amidoxime derivatives including nitrous derivatives of α-chloro-α-isonitrosoacetone and hydrochlorides of O-aroyl-β-aminopropioamidoximes and 3-[β-(piperidin-1-yl)]ethyl-5-aryl-1,2,4-oxadiazoles were tested for conduction, infiltration, and terminal anesthesia. There are four interesting “hit” compounds, i.e., the hydrochloride of O-m-chlorophenyl-β-(benzimidazol-1-yl)propioamidoxime...

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Pharmacology and structures of the free base of the anaesthetic kazcaine and its complex with β-cyclodextrin

U. S. Kemelbekov, A. Hagenbach, D. Lentz, Sh. O. Imachova, more

Journal of Inclusion Phenomena and Macrocyclic Chemistry > 2010 > 68 > 3-4 > 323-330

The base form of the local anaesthetic kazcaine (BFK, [1-(2-ethoxyethyl)-4-ethynyl-4-benzoyloxypiperidine, C₁₈H₂₃NO₃]) and β-cyclodextrin (β-CD) co-crystallized as BFK:β-CD inclusion complex in 1:2 M ratio from a mixture of water and ethanol while the filtered mother liquor yielded crystals of free BFK. X-ray diffraction showed that the crystals of BFK and its inclusion complex with β-CD belong to...

article

¹H NMR spectroscopy in the study of the three-dimensional structure of 7-alkoxyalkyl-3-thia-7-azabicyclo-[3.3.1]nonan-9-ones and some of their derivatives

S. G. Klepikova, V. K. Yu, E. E. Fomicheva, R. D. Mukhasheva, more

Chemistry of Heterocyclic Compounds > 2008 > 44 > 11 > 1398-1403

¹H NMR spectroscopy was used to establish that 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ones and their decarbonylated derivatives in deuterochloroform solution exist in the double chair conformation. The predominantly formed secondary alcohols isomers have preferred double chair conformation with the hydroxyl group equatorial relative to the plane of the piperidine ring. On the other hand,...

article

Synthesis and properties of N-(2-ethoxyethyl) piperidine derivatives of anabasine

A. Zh. Kabdraisova, M. F. Faskhutdinov, V. K. Yu, K. D. Praliev, more

Chemistry of Natural Compounds > 2007 > 43 > 4 > 437-440

The synthesis and pharmacological activity of ethers of 1-(2-ethoxyethyl)-4-[3-anabasin-1-yl-1-prop-1-ynyl]piperidin-4-ol were described.

article

Synthesis and structure of 7-alkoxyalkyl-3-thia-7-zabicyclo[3.3.1]nonan-9-ones and several of their derivatives

V. K. Yu, K. D. Praliev, E. E. Fomicheva, R. D. Mukhasheva, more

Chemistry of Heterocyclic Compounds > 2006 > 42 > 4 > 512-519

New 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ones were synthesized by the double Mannich cyclization of tetrahydrothiopyran-4-one with suitable alkoxyalkylamines and paraformaldehyde in acetous methanol. Wolff-Kishner decarbonylation of these bicyclic ketones gave 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonanes. The reduction of 7-alkoxyalkyl-3-thia-7-azabicyclo[3.3.1]nonan-9-ones by alkali...

article

Synthesis of 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)-ethyl]benzimidazole and its x-ray analysis

L. A. Kayukova, K. M. Beketov, A. L. Akhelova, K. D. Praliev

Chemistry of Heterocyclic Compounds > 2006 > 42 > 7 > 914-917

Cyclization of O-benzoyl-2-(benzimidazol-1-yl)propioamidoxime under different temperature conditions gave 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl]benzimidazole whose structure has been determined by X-ray analysis.

article

Synthesis of Secondary Alcohols and Their Esters from 4-Alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines

K. D. Praliev, I. A. Poplavskaya, B. Zh. Nauyryzova, M. A. Baimurzina, more

Russian Journal of General Chemistry > 2005 > 75 > 3 > 420-424

4-Alkoxy-4-(1-hydroxyethyl)-1-(2-ethoxyethyl)piperidines were prepared by reduction of 4-alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines. The esters of the hydroxyethyl derivatives were prepared. The presence of an asymmetric carbon atom in the molecules of the carbinols and their esters results in complication of their ¹H NMR spectra.

article

Synthesis of 1-(2-Ethoxyethyl)-4-hydroxy-4-[2-(1-hydroxycyclohexyl)ethynyl]piperidine and Heterocyclization under the Conditions of Hydration

K. B. Bazhykova, I. A. Poplavskaya, K. D. Praliev

Chemistry of Heterocyclic Compounds > 2005 > 41 > 11 > 1386-1389

The reaction of 1-(2-ethoxyethyl)piperidin-4-one with ethynylcyclohexanol led to the synthesis of a glycol, the hydration of which gave a mixture of spirocyclic compounds with a carbonyl group at various positions in the furan ring.

article

Crystal and molecular structure of β-piperidinopropioamidoxime monochloroacetate and hydrochlorides of its O-benzoylation products

K. M. Beketov, J. T. Welch, P. Toskano, L. A. Kayukova, more

Journal of Structural Chemistry > 2004 > 45 > 3 > 509-517

The structures of β-piperidinopropioamidoxime monochloroacetate and O-benzoyl- and O-para-toluyl-β-piperidinopropioamidoxime hydrochlorides have been determined. The geometry of these compounds is analyzed. The N-O bond is in the syn-planar position in β-piperidinopropioamidoxime monochloroacetate, but adopts an anti-orientation relative to the C(2)-C(3) bond of the propioamidoxime fragment in the...

article

Spatial Structure of Isomers of 3,7-Dialkoxyalkyl-3,7-diazabicyclo[3.3.1]nonan-9-ols

S. G. Klepikova, V. A. Solomin, T. K. Iskakova, V. K. Yu, more

Chemistry of Heterocyclic Compounds > 2003 > 39 > 4 > 504-510

The spatial structure of 3,7-dialkoxyalkyl-3,7-diazabicyclo[3.3.1]nonan-9-ols has been investigated with the aid of ¹H and ¹³C NMR spectroscopy. It was shown that the secondary alcohols studied exist in solution predominantly in a chair-boat conformation which proved to be energetically more favorable than a chair-chair conformation due to the formation of an intramolecular hydrogen bond (IMHB) between...

article

Study of the Steric Structure of 7-Alkoxyalkyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ones and Their Derivatives Using ¹H NMR Spectroscopy

S. G. Klepikova, V. K. Yu, E. E. Fomicheva, R. D. Mukhasheva, more

Chemistry of Heterocyclic Compounds > 2003 > 39 > 10 > 1376-1384

Using the ¹H NMR spectroscopic method it has been shown that 7-alkoxyalkyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ones and 7-alkoxyalkyl-3-oxa-7-azabicyclo[3.3.1]nonanes exist in deuterochloroform solution in a double chair conformation. 7-(3-Butoxypropyl)-3-oxa-7-azabicyclo[3.3.1]nonan-9-ol is a 1:1 mixture of the two stereoisomeric alcohols. One of them exists in a double chair conformation having an...

article

Synthesis, Antibacterial, and Analgesic Activity of 1-(2-Ethoxyethyl)-4-hydroxy(acyloxy)-piperidine-4-carboxylic Acids

V. K. Yu, A. D. Nagimova, K. D. Praliev, S. N. Shin, more

Pharmaceutical Chemistry Journal > 2002 > 36 > 7 > 382-384

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Keywords

Β-CYCLODEXTRIN (4)
NMR SPECTROSCOPY (3)
PHARMACOLOGICAL PROPERTIES (3)
STRUCTURE (3)
CHAIR-BOAT (2)
ANAESTHETIC (2)
CONFORMATION (2)
CRYSTAL STRUCTURE (2)
CYCLODEXTRIN (2)
INCLUSION COMPLEX (2)
INCLUSION COMPLEXES (2)
13C NMR SPECTRA (1)
1H AND 13C NMR SPECTROSCOPY (1)
1H NMR (1)
1H NMR SPECTRA (1)
CHAIR-CHAIR (1)
1-(2-ETHOXYETHYL)-4-(PENTYN-1-YL)-4-BENZOYLOXY-PIPERIDINE OXALATE (1)
1-(2-ETHOXYETHYL)-4-(PENTYN-1-YL)-4-HYDROXYPIPERIDINE (1)
1-(2-ETHOXYETHYL)PIPERIDIN-4-ONE (1)
1-(3-N-BUTOXYPROPYL)-4-VINYLACETYLENE-4-BENZOYLOXYPIPERIDINE (1)
1-ETHYNYL-1-HYDROXYCYCLOHEXANE (1)
2-[2-(5-PHENYL-1,2,4-OXADIAZOL-3-YL)-ETHYL]BENZIMIDAZOLE (1)
3,7-DIALKOXYALKYL-3,7-DIAZABICYCLO[3.3.1]NONAN-9-OL (1)
3,7-DIAZABICYCLO[3.3.1]NONANES (1)
3-(2′-ETHOXYETHYL)-14(15)-OXO-7-OXA-3-AZADISPIRO[5,1,5,2]PENTADECANE (1)
3-[Β-(PIPERIDIN-1-YL)]ETHYL-5-ARYL-1,2,4-OXADIAZOLES (1)
4-ACYLOXY-4-(CYCLOPROPYLETHYNYL)-1-(2-ETHOXYETHYL)PIPERIDINES (1)
7-(2-MORPHOLINOETHYL)-3-(2-ETHOXYETHYL)-3,7-DIAZABICYCLO[3.3.1]NONANE (1)
7-ALKOXYALKYL-3-OXA-7-AZABICYCLO[3.3.1]NONAN-9-ONE DERIVATIVES (1)
7-ALKOXYALKYL-3-THIA-7-AZABICYCLO[3.3.1]NON-9-ONE AND ITS DERIVATIVES (1)
7-ALKOXYALKYL-3-THIA-7-AZABICYCLO[3.3.1]NONAN-9-ONE AND ITS DERIVATIVES (1)
ANABASINE (1)
ANESTHETIC ACTIVITY (1)
ARTEMIA SALINA LEACH BRINE SHRIMP (1)
BISPIDINONES (1)
CONDUCTION (1)
CONDUCTION, INFILTRATION, AND SPINAL ANESTHESIA (1)
CONFORMATIONAL ANALYSIS (1)
CYTOTOXICITY (1)
DEHYDRATION (1)
EPINEPHRINE (1)
ETHERS (1)
FAVORSKY REACTION (1)
HYDRATION (1)
HYDROCHLORIDES OF O-AROYL-Β-AMINOPROPIOAMIDOXIMES (1)
HYDROGEN BONDS (1)
IMMUNOSTIMULATORY ACTIVITY (1)
INFILTRATION (1)
KAZCAINE BASE (1)
MANNICH REACTION (1)
MYELOSTIMULATORY ACTIVITY (1)
NITROUS DERIVATIVES OF Α-CHLORO-Α-ISONITROSOACETONE (1)
O-BENZOYL- AND O-PARA-TOLUYL-Α-PIPERIDINOPROPIOAMIDOXIMES (1)
O-BENZOYL-2-(BENZIMIDAZOL-1-YL)PROPIOAMIDOXIME (1)
PIPERIDINE (1)
PROPARGYLAMINES (1)
PURPURIN (1)
ROESY (1)
SATURATED CYCLIC CARBOXYLIC ACID CHLORIDES (1)
SYNTHESIS (1)
TERMINAL ANESTHESIA (1)
VASOCONSTRICTOR (1)
X-RAY ANALYSIS (1)
X-RAY DIFFRACTION (1)
Α-, Β-, AND Γ-CYCLODEXTRIN (1)
Β-PIPERIDINOPROPIOAMIDOXIME (1)
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Search results for: K. D. Praliev

Synthesis of Monosubstituted Purpurins and Their Biological Activity

Supramolecular inclusion complexes of β-cyclodextrin with 4-(acyloxy)-4-(cyclopropylethynyl)-1-(2-ethoxyethyl)piperidines

The structure and pharmacological properties of the 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine inclusion complex with β-cyclodextrin

Local Anesthetic Activity of a Promising Piperidine Derivative (LAS-54) in Combination with Epinephrine

Investigation of supramolecular inclusion complexes with β-cyclodextrin of 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-hydroxypiperidine and 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-benzoyloxypiperidine oxalate by NMR spectroscopy

Synthesis and Myelostimulatory Activity of a Number of 3,7-Diazabicyclo[3.3.1]Nonane Derivatives

NMR study of supramolecular inclusion complexes of 7-[2-(morpholin-4-yl)ethyl]-3-(2-ethoxyethyl)-3,7-diazabicyclo[3.3.1]nonane with cyclodextrins

Preparation of an Inclusion Complex of 1-(3-n-butoxypropyl)-4-vinylacetylen-4-benzoyloxypiperidine with B-cyclodextrin and its Local Anesthetic Activity

Local anesthetic activity of new amidoxime derivatives

Pharmacology and structures of the free base of the anaesthetic kazcaine and its complex with β-cyclodextrin

¹H NMR spectroscopy in the study of the three-dimensional structure of 7-alkoxyalkyl-3-thia-7-azabicyclo-[3.3.1]nonan-9-ones and some of their derivatives

Synthesis and properties of N-(2-ethoxyethyl) piperidine derivatives of anabasine

Synthesis and structure of 7-alkoxyalkyl-3-thia-7-zabicyclo[3.3.1]nonan-9-ones and several of their derivatives

Synthesis of 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)-ethyl]benzimidazole and its x-ray analysis

Synthesis of Secondary Alcohols and Their Esters from 4-Alkoxy-4-acetyl-1-(2-ethoxyethyl)piperidines

Synthesis of 1-(2-Ethoxyethyl)-4-hydroxy-4-[2-(1-hydroxycyclohexyl)ethynyl]piperidine and Heterocyclization under the Conditions of Hydration

Crystal and molecular structure of β-piperidinopropioamidoxime monochloroacetate and hydrochlorides of its O-benzoylation products

Spatial Structure of Isomers of 3,7-Dialkoxyalkyl-3,7-diazabicyclo[3.3.1]nonan-9-ols

Study of the Steric Structure of 7-Alkoxyalkyl-3-oxa-7-azabicyclo[3.3.1]nonan-9-ones and Their Derivatives Using ¹H NMR Spectroscopy

Synthesis, Antibacterial, and Analgesic Activity of 1-(2-Ethoxyethyl)-4-hydroxy(acyloxy)-piperidine-4-carboxylic Acids

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