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A decrease in ribosomal gene activity is an essential feature ofthe aging process as it was observed in Alzheimer's disease, inelderly Down's patients and in elderly healthy people. It is wellknown that aging is also associated with a reduction in melatoninsynthesis. We studied 24 male Wistar rats cytogenetically, byusing Ag-stained NOR (6 three-month-old rats underwent pinealectomyand were studied...