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Aiolos and Ikaros encode hemopoietic-specific zinc finger transcription factors that are important regulators of lymphocyte differentiation. Aiolos and Ikaros play a critical role in regulating B and T cell development. Gene targeting studies in mice have shown that inactivation of Ikaros family proteins leads to a complete absence of T, B, NK and dendritic cells, whereas a reduction of Ikaros activity...
Introduction: Human thymus contains a small population of B cells. A number of features have been reported characteristic of thymic B cells such as the presence of a CD2+CD19+ in human thymic cell population, an increased expression of CD5 at least in the mouse and a lower reactivity to LPS, anti-μ antibody or IL4, but the origin and functions of these cells remained to be elucidated.Materials and...
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