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Protein phosphorylation is a critical cellular process regulated by the competing actions of protein kinases (PKs) and phosphatases (PPs). While several hundred PKs exist in mammalian cells, there are only a few dozen PPs. PPs typically target Ser/Thr or Tyr residues but each has different characteristics and specificities and fall into three separate classes. PPs on their own have poor substrate...
Aged rhesus monkeys exhibit deficits in hippocampus-dependent memory, similar to aging humans. Here we explored the basis of cognitive decline by first testing young adult and aged monkeys on a standard recognition memory test (delayed nonmatching-to-sample test; DNMS). Next we quantified synaptic density and morphology in the hippocampal dentate gyrus (DG) outer (OML) and inner molecular layer (IML)...
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