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Abstract. In mammals, adrenomedullary chromaffin cells (AMC) express a neutrophil-like NADPH oxidase and secrete catecholamines, which play a vital role in the ability of the neonate to survive hypoxic stress. To test whether NADPH oxidase functions as an O2 sensor, and whether mouse AMC express a developmentally regulated O2-sensing mechanism similar to rats, we compared the effects of hypoxia on...