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Conclusions TLRs represent attractive drug targets for the modulation of the immune response and hold promising applications for the treatment of infection and inflammation as well as for the development of vaccine adjuvants. Two main strategies for targeting TLRs seem to be promising for drug development: targeting TLRs with synthetic agonists or antagonists and targeting the protein-protein interaction...
Galanin is a 29- to 30-aa-long neuropeptide affecting feeding, cognitive, and sexual behavior. It exerts its effects through galanin receptors 1, 2 and 3, which are all seven transmembrane domain G-protein coupled receptors (GPCRs). The GPCRs have been shown to function as monomers, homodimers, heterodimers and oligomers. In this study, we examined the extent of galanin receptor 1 (GalR1) dimerization...
Chemokine receptors belong to the superfamily of seven-transmembrane-spanning, G-protein-coupled receptors, and their expression by central nervous system cells is clearly documented. As this gene family has become the target of novel therapeutic development, the analysis of these receptors requires radioligand binding techniques as well as methods that entail assessing receptor stimulation of signal...
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