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BACKGROUND AND AIMS: We have previously reported that whisker-shock fear conditioning produced expansion of the cortical representation of the activated vibrissae (“trained row”), this was demonstrated by labeling with 2-deoxyglucose in layer IV of the barrel cortex. Functional reorganization of the primary somatosensory cortex was accompanied by an increase in the density of small GABAergic neurons,...
Linker histone H1 participates in maintaining higher order chromatin structures. It is a dynamic protein that binds to DNA and exchanges rapidly with a mobile pool. Therefore, the dynamics of H1 were probed in the nuclei of intact, live cells, using an array of microscopy techniques: fluorescence recovery after photobleaching (FRAP), raster image correlation spectroscopy (RICS), fluorescence correlation...
Studies on insulin resistance of liver cells are often performed with the use of various hepatoma cell lines. Such an approach allows investigating selected biochemical pathways at the cellular level. However, possible modifications of metabolic processes due to the neoplastic nature of such cells must be considered. Expanding the diversity of hepatoma cell lines used in metabolic studies could deliver...
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