Search results for: Bryan H. King

Despite the high rate of anxiety in individuals with autism spectrum disorder (ASD), measuring anxiety in ASD is fraught with uncertainty. This is due, in part, to incomplete consensus on the manifestations of anxiety in this population. Autism Speaks assembled a panel of experts to conduct a systematic review of available measures for anxiety in youth with ASD. To complete the review, the panel held...

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STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study

Craig A. Erickson, Jeremy M. Veenstra-Vanderweele, Raun D. Melmed, James T. McCracken, more

Journal of Autism and Developmental Disorders > 2014 > 44 > 4 > 958-964

STX209 (arbaclofen), a selective GABA-B agonist, is hypothesized to modulate the balance of excitatory to inhibitory neurotransmission, and has shown preliminary evidence of benefit in fragile X syndrome. We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32 children and adolescents with either Autistic Disorder or...

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DSM-5 and Autism: Kicking the Tires and Making the Grade

Bryan H. King, Jeremy Veenstra-VanderWeele, Catherine Lord

Journal of the American Academy of Child & Adolescent Psychiatry > 2013 > 52 > 5 > 454-457

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Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders

Victoria Hallett, Luc Lecavalier, Denis G. Sukhodolsky, Noreen Cipriano, more

Journal of Autism and Developmental Disorders > 2013 > 43 > 10 > 2341-2352

This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety...

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Commentary from the DSM-5 Workgroup on Neurodevelopmental Disorders

Susan E. Swedo, Gillian Baird, Edwin H. Cook, Francesca G. Happé, more

Journal of the American Academy of Child & Adolescent Psychiatry > 2012 > 51 > 4 > 347-349

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Consensus Paper: Pathological Role of the Cerebellum in Autism

S. Hossein Fatemi, Kimberly A. Aldinger, Paul Ashwood, Margaret L. Bauman, more

The Cerebellum > 2012 > 11 > 3 > 777-807

There has been significant advancement in various aspects of scientific knowledge concerning the role of cerebellum in the etiopathogenesis of autism. In the current consensus paper, we will observe the diversity of opinions regarding the involvement of this important site in the pathology of autism. Recent emergent findings in literature related to cerebellar involvement in autism are discussed,...

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Is schizophrenia on the autism spectrum?

Bryan H. King, Catherine Lord

Brain Research > 2011 > 1380 > Complete > 34-41

With the ongoing consideration of the diagnostic criteria for mental disorders that is active in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) and International Classification of Diseases (ICD-11) revision processes, it is timely to review the phenomenological overlap between autism and schizophrenia. These disorders have at various times been regarded alternatively as closely...

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The association between short and long nocturnal sleep durations and risky behaviours and the moderating factors in Taiwanese adolescents

Cheng-Fang Yen, Bryan H. King, Tze-Chun Tang

Psychiatry Research > 2010 > 179 > 1 > 69-74

Sleep quantity and risky behaviours are important health issues in adolescents. This cross-sectional study aimed to examine the association between short and long nocturnal sleep durations and a variety of adolescent risky behaviours, including suicidality, violence, regular alcohol consumption, illicit drug use, truancy, unprotected sex, tattooing and criminal record of theft in a large-scale, representative...

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Factor structure of the Athens Insomnia Scale and its associations with demographic characteristics and depression in adolescents

CHENG‐FANG YEN, BRYAN H. KING, YU‐PING CHANG

Journal of Sleep Research > 19 > 1‐Part‐I > 12 - 18

The eight‐item Athens Insomnia Scale (AIS‐8) is an instrument that has been used frequently to assess insomnia problems. Previous research on adults has found that the AIS‐8 functioned as a sole component. This study aimed to examine the prevalence rates of insomnia problems on the AIS‐8, the factor structure of the AIS‐8 in adolescents and its associations with demographic characteristics and depression...

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The quality of health care for adults with developmental disabilities

Mary Ann Lewis, Charles E. Lewis, Barbara Leake, Bryan H. King, more

Public Health Reports > 2002 > 117 > 2 > 174-184

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Autism spectrum disorders: Update of evaluation and treatment

Ashraf G. Mikhail, Bryan H. King

Current Psychiatry Reports > 2001 > 3 > 5 > 361-365

Autistic spectrum disorders are a group of neuro-developmental conditions that are increasingly capturing the attention of clinicians and investigators. New insights from genetics and neuropathophysiology of autism will increasingly inform treatment. Presently, individualized treatment approaches typically include a mix of behavioral and, occasionally, pharmacotherapeutic strategies. Concerning the...

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Pharmacological Treatment of Mood Disturbances, Aggression, and Self-Injury in Persons with Pervasive Developmental Disorders

Bryan H. King

Journal of Autism and Developmental Disorders > 2000 > 30 > 5 > 439-445

Aggression, self-injury, and mood disturbances in persons with autistic disorders, while not uncommon, do not constitute core features of autism. Moreover, these problems can occur for a variety of reasons, which need to be assessed in order to plan appropriate and frequently combined (behavioral-pharmacological) treatments. Drugs acting primarily in the dopaminergic, serotonergic, adrenergic, opioidergic,...

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Pemoline produces ipsilateral turning behavior in unilateral 6-ohda-lesioned rats

Howard C. Cromwell, Elise A. Witte, Cynthia A. Crawford, T Ly Hoa, more

Progress in Neuropsychopharmacology & Biological Psychiatry > 1996 > 20 > 3 > 503-514

1. Male Sprague-Dawley rats received either a unilateral injection of 6-hydroxy-dopamine or vehicle injection into the medial forebrain bundle.2. Two weeks post surgery, all rats received a pemoline challenge (250 mg/kg s.c.), and rotational and stereotyped behaviors were videotaped and analyzed.3. All rats regardless of injection expressed stereotyped behaviors and hyper-locomotion after pemoline...

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Search results for: Bryan H. King

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